An interventional study of High Intensity Interval Training in Asthma, sponsored by Bispebjerg Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2021-03-15.
Sponsored by Bispebjerg Hospital · Not applicable, Interventional, and Treatment
Among 19 studies in Asthma by Bispebjerg Hospital — none open to participants now, none under way, none of them phase 3. Asthma · Bispebjerg Hospital.
Among the 19 studies in Asthma by Bispebjerg Hospital, this one has the largest enrollment of the 11 interventional ones that give a count, is one of 2 that started in 2017, is one of 4 with no phase, and was the 14th registered.
4,841 studies on the registry are indexed under Asthma; 600 are open to participants now.
Browse Asthma studies →None of the 19 studies in Asthma by Bispebjerg Hospital is open now.
Of the 417 Asthma studies recruiting now, 140 (34%) set no upper age limit and 205 (49%) stop at 75 or younger; 146 take children under 18; 104 take healthy volunteers.
This study: 18 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
19 studies; the count open now beside each. This study's row is marked.
First in 2000; this study’s year is marked. 2 started in 2017.
This study's enrollment of 150 is above the median of 78 across 3,341 interventional studies indexed under Asthma.
Median enrollment 39 across the 11 interventional studies, 70 across the 8 observational. Of the 11 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
Bispebjerg Hospital is the lead sponsor of 289 studies on the registry; 29 are open to participants now.
None of the studies under way reaches primary completion within a year.
Among the 19 studies in Asthma by Bispebjerg Hospital, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
To evaluate if physical exercise intervention leads to an improved asthma control as measured by Asthma Control Questionnaire (ACQ-5) in such a magnitude that inhaled corticosteroid can be reduces in asthmatics.
At least 102 asthmatics will be randomized 2:1 (2 to training group; 1 to control) and undergo 6 months of intervention or usual lifestyle.
Subjects must have confirmed asthma diagnosis, on a stable treatment with inhaled corticosteroid, symptomatic and untrained.
At enrollment and during the study asthma medicine is adjusted based on asthma symptoms evaluated by ACQ-5. 6 treatment steps are pre-defined, and if well controlled asthma, subjects are down-titrated one step, if uncontrolled, subjects are uptitrated one step.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Subjects, who by investigators determination, will not be able to adhere to study protocol
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
NYHA class (heart failure)
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ECG (electrocardiogram)
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Supervised High intensity interval training (HIIT) 3 times a week for 6 months. Training session: 10 minutes warm up (Low-moderate intensity) 30 minutes intervention (16 minutes HIIT) 10 minutes cool down(Low-moderate intensity)
Behavioral: High Intensity Interval Training
Control group, usual lifestyle. Aside from training intervention, all other visits are the same as intervention group (training).
Training (HIIT)
Also known as: Training group
Reduced inhaled corticosteroid (ICS) 6 months
The proportion of participants at 6 months that have been down-titrated in ICS dose by at least 25% compared to the participants' baseline dose
Time frame: 6 months +/- 7 days
Reduced inhaled corticosteroid (ICS) 12 months
The proportion of participants at 12 months that have been down-titrated in ICS dose by at least 25 % compared to baseline.
Time frame: 12 months +/- 7 days
Cumulated ICS 6 months
Change from baseline in cumulated dose of ICS at 6 months
Time frame: 6 months +/- 7 days
Cumulated ICS 12 months
Change from baseline in cumulated dose of ICS at 12 months
Time frame: 12 months +/- 7 days
Cumulated Long acting beta2 agonists (LABA) 6 months
Change from baseline in cumulated dose of LABA at 6 months
Time frame: 6 months +/- 7 days
Cumulated LABA 12 months
Change from baseline in cumulated dose of LABA at 12 months
Time frame: 12 months +/- 7 days
Exacerbation rate 6 months
Number of exacerbations (moderate-severe) at 6 months
Time frame: 6 months +/- 7 days
Exacerbation rate 12 months
Number of exacerbations (moderate-severe) at 12 months
Time frame: 12 months +/- 7 days
miniAQLQ 6 months
Change from baseline in Asthma life quality evaluated by miniAQLQ at 6 months
Time frame: 6 months +/- 7 days
miniAQLQ 12 months
Change from baseline in Asthma life quality evaluated by miniAQLQ at 12 months
Time frame: 12 months +/- 7 days
Fraction of exhaled Nitrogen Oxid 6 months
Change from baseline in Airway inflammation evaluated by FeNO at 6 months
Time frame: 6 months +/- 7 days
Fraction of exhaled Nitrogen Oxid 12 months
Change from baseline in Airway inflammation evaluated by FeNO at 12 months
Time frame: 12 months +/- 7 days
Sputum cell count 6 months
Change from baseline in Airway inflammation evaluated by sputum cell count at 6 months
Time frame: 6 months +/- 7 days
Sputum cell count 12 months
Change from baseline in Airway inflammation evaluated by sputum cell count at 12 months
Time frame: 12 months +/- 7 days
Systemic inflammation 6 months
Change from baseline in systemic inflammation evaluated by blood eosinophilic, hsCRP and inflammatory cytokines (e.g. IL-6 and IL-8) and TNF-alfa at 6 months
Time frame: 6 months +/- 7 days
Systemic inflammation 12 months
Change from baseline in systemic inflammation evaluated by blood eosinophilic, hsCRP and inflammatory cytokines (e.g. IL-6 and IL-8) and TNF-alfa at 12 months
Time frame: 12 months +/- 7 days
Airway hyperresponsiveness
Change from baseline in airway hyperresponsiveness measured by methacholine test at 6 months
Time frame: 6 months +/- 7 days
FEV1 6 months
Change from baseline in lung function evaluated by FEV1 at 6 months
Time frame: 6 months +/- 7 days
FVC 6 months
Change from baseline in lung function evaluated by FVC at 6 months
Time frame: 6 months +/- 7 days
FEV1 12 months
Change from baseline in lung function evaluated by FEV1 at 12 months
Time frame: 12 months +/- 7 days
FVC 12 months
Change from baseline in lung function evaluated by FVC at 12 months
Time frame: 12 months +/- 7 days
Cardiopulmonary fitness
Change from baseline in cardiopulmonary fitness evaluated by maximum oxygen consumption at 6 months (VO2max)
Time frame: 6 months +/- 7 days
Change in fat and muscle composition (DEXA scan)
Change from baseline in fat and muscle composition evaluated by DEXA scan
Time frame: 6 months +/- 7 days
Eosinophilic subpopulation - exploratory analyses 6 months
To evaluate the effect of the intervention in sub-populations of asthmatics using different cut-off values of blood eosinophilics. Both regarding primary outcome and secondary outcomes.
Time frame: 6 months +/- 7 days
Eosinophilic subpopulation - exploratory analyses 12 months
To evaluate the effect of the intervention in sub-populations of asthmatics using different cut-off values of blood eosinophilics with regards to secondary outcomes at 12 months.
Time frame: 12 months +/- 7 days
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Ran from Oct 2017 to primary completion in Jun 2020, 32 months.
Of 599 non-industry interventional studies with no phase under Asthma, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 50. This study's 32 months is above that.
Counting every sponsor, half of 649 studies reached it within 23 months; a quarter within 10 and three quarters within 48.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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