An observational study in Chronic Kidney Disease Mineral and Bone Disorder, sponsored by Great Ormond Street Hospital for Children NHS Foundation Trust. Status unknown at 1 site in United Kingdom. Open to participants aged Up to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-16.
Sponsored by Great Ormond Street Hospital for Children NHS Foundation Trust · Observational
This is a novel, non-invasive method of assessing Ca balance by natural Ca isotope fractionation.
Detailed description and study protocol will be available to individuals on request.
73 studies on the registry are indexed under Chronic Kidney Disease-Mineral and Bone Disorder; 20 are open to participants now.
This study's enrollment of 120 is below the median of 164 across 36 observational studies indexed under Chronic Kidney Disease-Mineral and Bone Disorder.
Browse Chronic Kidney Disease-Mineral and Bone Disorder studies →Great Ormond Street Hospital for Children NHS Foundation Trust is the lead sponsor of 82 studies on the registry; 19 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All children with chronic kidney disease stage 3-5 and on dialysis and age matched controls
I - For healthy children
Inclusion criteria
Exclusion criteria
II - For CKD and dialysis children
Inclusion criteria
Exclusion criteria
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
GFR and eGFR (kidney filtering)
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Children of all ages with an eGFR \<60ml/min/1.73m2, including those on dialysis
Diagnostic Test: Collection of blood, urine and stool samples
1. All children \<18 years 2. Normal renal function (eGFR 90-120ml/min/1.73m2 \[calculated by Schwartz formula\] in children \>1 year and serum creatinine \<35μMol/L in children \<1 year) 3. Weight, height and BMI within 2 SD of normal using WHO growth charts In order to make this study as 'real-life' as possible, free-living UK children on their usual diet and dietary supplementation (including Ca and Vit D), if any, will be included, but analysis will account for medication doses and blood levels.
Diagnostic Test: Collection of blood, urine and stool samples
Collection of blood, urine and stool samples, diet diary and bone scans
Also known as: DEXA - lumbar spine and hips, tibial peripheral quantitative CT, Dietary record
Calcium isotope fractionation in blood, urine and stool in healthy children and those with CKD
available on request
Time frame: 24 months
number of children with fractures, and clinical and biochemical correlates of fractures
available on request
Time frame: 12 months
Bone scans - whole body & lumbar spine DEXA, bone mineral density on tibial peripheral quantitative CT scan
available on request
Time frame: 24 months
Plan to share: Undecided — IPD sharing will be considered at the end of the study.
No publications or documents are linked to this record.
This study is status unknown, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Chronic Kidney Disease-Mineral and Bone Disorder →
Great Ormond Street Hospital for Children NHS Foundation Trust