An observational study in Iron Metabolism Disorders, sponsored by Victor Gordeuk. Completed at 1 site in United States. Open to female participants aged 25 Years to 44 Years. Per ClinicalTrials.gov, last updated 2017-09-08.
Sponsored by Victor Gordeuk · Observational
Analyzed iron status, HFE mutations and ethnicity for women in five primary care centers in the United States and Canada using de-identified data from the HEIRS study.
HEIRS included a cross-sectional screening study of 101,168 patients, 25 years of age or older, in the primary care setting. Participants were recruited from four centers in the U.S .and one in Canada from February 2001 to February 2003. We will evaluate results for women aged 25-44 years of age who are self-reported as Asian, Black, Hispanic or White. The lower detection limit for the serum ferritin (SF) assay in the HEIRS study was 15 μg/L and therefore the definition of iron deficiency will be SF concentration ≤ 15 μg/L. Elevated SF concentrations, possibly indicative of elevated iron stores, will be classified by two definitions: 1) SF concentration > 300 μg/L and 2) SF >200 μg/L in combination with TSAT >45%. Proportions will be compared by Pearson's chi-square. Logistic regression models will be used to identify independent associations with measures of iron deficiency and elevated iron stores.
Primary care women included in the HEIRS study.
Exclusion Criteria:
Women 25 to 44 years of age recruited in a primary care setting and self reported as Asian American and non-pregnant/non-breastfeeding.
Other: observation
Women 25 to 44 years of age recruited in a primary care setting and self reported as African American and non-pregnant/non-breastfeeding.
Other: observation
Women 25 to 44 years of age recruited in a primary care setting and self reported as Hispanic American and non-pregnant/non-breastfeeding.
Other: observation
Women 25 to 44 years of age recruited in a primary care setting and self reported as white and non-pregnant/non-breastfeeding.
Other: observation
Women 25 to 44 years of age recruited in a primary care setting and self reported as Asian American and pregnant or breastfeeding.
Other: observation
Women 25 to 44 years of age recruited in a primary care setting and self reported as African American and pregnant or breastfeeding.
Other: observation
Women 25 to 44 years of age recruited in a primary care setting and self reported as Hispanic American and pregnant or breastfeeding.
Other: observation
Women 25 to 44 years of age recruited in a primary care setting and self reported as White and pregnant or breastfeeding.
Other: observation
observation
Elevated serum ferritin
Serum ferritin \>300 ug/L
Time frame: One measurement was made at the time of recruitment and this is the measurement that will be analyzed.
Elevated serum ferritin and transferrin saturation
Serum ferritin \>200 ug/L and transferrin saturation \>45%
Time frame: One measurement was made at the time of recruitment and this is the measurement that will be analyzed.
Iron deficiency
Serum ferritin \<15ug/L
Time frame: One measurement was made at the time of recruitment and this is the measurement that will be analyzed.
Plan to share: No
This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.
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