An interventional study of exercise training in Healthy, sponsored by Morten Hostrup, PhD. Completed at 1 site in Denmark. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-01-15.
Sponsored by Morten Hostrup, PhD · Not applicable, Interventional, and Basic science
The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men
Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.
Exclusion Criteria:
12-15 training sessions of 30 min over 4-5 weeks
Other: exercise training
subjects complete 4-5 weeks of training
Skeletal muscle proteome signature
proteomics
Time frame: Change from baseline proteome signature at 5 weeks
Skeletal muscle acetylome signature
acetylomics
Time frame: Change from baseline acetylome signature at 5 weeks
Skeletal muscle mitochondrial respiration
Mitochondrial respiratory capacity
Time frame: Change from baseline at 5 weeks
Maximal oxygen uptake
Maximal oxygen uptake
Time frame: Change from baseline at 5 weeks
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.
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Morten Hostrup, PhD