An interventional study of Nandrolone Decanoate and Dexamethasone in Cachexia; Cancer, sponsored by Hospital Erasto Gaertner. Completed at 1 site in Brazil. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-02-26.
Sponsored by Hospital Erasto Gaertner · Not applicable, Interventional, and Supportive care
Compare the use of nandrolone associated with corticosteroid for the treatment of cancer-induced malnutrition to treatment with corticosteroids alone in patients with tumors in the high gastro-intestinal tract, liver, pancreas and bile ducts in palliative treatment.
331 studies on the registry are indexed under Cachexia; 75 are open to participants now.
This study's enrollment of 60 is below the median of 74 across 226 interventional studies indexed under Cachexia.
Browse Cachexia studies →Hospital Erasto Gaertner is the lead sponsor of 3 studies on the registry; none are open to participants now.
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Exclusion Criteria:
the patient will receive an application of anabolic nandrolone decanoate at a dose of 50 mg (males) and 25 mg (females), intra-muscular form, in the first and fifteenth days. In addition to the anabolic steroid, the patient will use corticosteroids (dexamethasone) at home at a dose of 4 mg daily by mouth on the morning for both sexes for 30 days.
Drug: Nandrolone Decanoate
Patient will take corticosteroids ( 4 mg of dexamethasone) per oral, QD at morning for 30 days
Drug: Dexamethasone
Drug administration
Also known as: Dexamethasone
Drug administration
Compare the use of nandrolone associated with corticosteroid for the treatment of cancer-induced malnutrition to treatment with corticosteroids alone in cancer patients
Evaluate the BMI ( body mass index)- the weight in kilograms and the height in centimeters and BMI in Kg/ m2.
Time frame: After 30 days, the values will be compared to those obtained on the first consultant.
Compare the use of nandrolone associated with corticosteroid for the treatment of cancer-induced malnutrition to treatment with corticosteroids alone in cancer patients by bioimpedance analysis ( BIA)
Evaluate the BIA (biometrical impedance analysis)trough the reactance and resistance in ohms and the phase angle in degree.
Time frame: After 30 days, the values will be compared to those obtained on the first consultant.
ompare the use of nandrolone associated with corticosteroid for the treatment of cancer-induced malnutrition to treatment with corticosteroids alone in cancer patients trough quality of life assessment
Evaluate quality of life by European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnare Core 30 ( QLQ-C30), version 3.0 . The values are expressed as a percentage
Time frame: After 30 days, the values will be compared to those obtained on the first consultant.
Compare data from laboratory tests: complete blood count, albumin, C reactive protein and transferrin with drug intervention.
The complete blood count will be expressed in millions by cubic milimiter( millions/mm3) , albumin in grams per deciliter (g/dL), C reactive protein in milligrams per deciliter (mg/dL), transferrin in milligrams per deciliter (mg/dL)
Time frame: After 30 days, the laboratory test will be collect again and the values will be compared to those obtained on the first consultant.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Nandrolone Decanoate
Hospital Erasto Gaertner