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CompletedNCT03260829mesotherapyUpdated Aug 29, 2017

Efficacy of Injectable Vitamin C on Accelerating Canine Movement: A Clinical Study

An interventional study of vitamin C in Palatally Impacted Canines, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 15 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-08-29.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Non-randomized
Ages
15 Years to 40 Years
Sex
All
01

Study summary

efficacy of the injectable vitamin C to reduce the time of canine traction

Read the detailed description

Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the enhancement of the palatally impacted canine movement.

Design. Twelve adult patients with unilateral palatally impacted canines were included in this study. The enrolled patients were randomly allocated into the study groups; control group; orthodontic traction and he test group: orthodontic traction enhanced by intraepidermic vitamin C injection. The study duration was 12 months.

02

Conditions studied

  • Palatally Impacted Canines

Keywords

  • vitamin C
  • palatally impacted canines
  • intraepidermal injection
03

In context

Lead sponsor

Cairo University is the lead sponsor of 4,941 studies on the registry; 1,457 are open to participants now.

Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Browse Cairo University studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
15 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • medically free
  • patient with good to fair oral hygiene (gingivitis may be included)
  • both sexes were included
  • unilateral palatally positioned permenant canines
  • absence of previous orthodontic treatment
  • absence of supernumerary teeth, odontoms, cysts, traumatic injuries
  • the α angle within grade II to III

Exclusion criteria

Exclusion Criteria:

  • systemic diseases especially diabetes and bone diseases
  • pregnant and lactating mothers
  • Local causes (smoking, mouth breathing, local trauma and periodontitis).
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
12 participants (actual)

Study arms

  • Active comparator
    vitamin C injection

    orthodontic traction with vitamin C injection

    Drug: vitamin C

  • Placebo comparator
    orthodontic traction

    orthodontic traction without vitamin C injection

    Drug: vitamin C

Interventions

  • Drugvitamin C

    25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved

    Also known as: ascorbic acid

06

What researchers measure

Primary outcomes

  1. rate of tooth movement

    the achieved movement in millimeters in one year

    Time frame: 12 months

Secondary outcomes

  1. level of alveolar bone

    the level of the interproximal and facial alveolar bone after orthodontic treatment with or without injection

    Time frame: 12 months

07

Study locations

1 site
  • Faculty of Oral and Dental Medicine
    Gizah, Giza 11311, Egypt
08

References and documents

Publications

  • Makar AB, McMartin KE, Palese M, Tephly TR. Formate assay in body fluids: application in methanol poisoning. Biochem Med. 1975 Jun;13(2):117-26. doi: 10.1016/0006-2944(75)90147-7. No abstract available. PubMed 1 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Jan 2014, a primary completion of Jan 2015 and a completion of Feb 2015. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 11, 2017
First posted
Aug 24, 2017
Start
Jan 2014
Primary completionActual
Jan 2015
CompletionActual
Feb 2015
Last update
Aug 29, 2017
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 29, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03260829
Lead sponsor
Cairo University
Responsible party
nermin mohammed ahmed yussif (assistant lecturer, Cairo University) — Principal investigator
First posted
Aug 24, 2017
Start date
Jan 2014
Primary completion
Jan 2015
Completion
Feb 2015
Last update
Aug 29, 2017

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.

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Studies of the drug tested here: Ascorbic Acid

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