An observational study in Enalapril Adverse Reaction, Pharmacogenomics and Stroke, sponsored by Cui Yimin. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-08-28.
Sponsored by Cui Yimin · Observational
Dry cough is the most common adverse reaction of angiotensin converting enzyme, including enalapril, in Chinese population. Clinical observations suggest that the incidence of ACEI-induced dry cough is different between Chinese and other racial groups, however, there is still lack of research data in Chinese. Stroke is the second leading cause of death in the world and leading cause of death in China. Except the known risk factor such as hypertension, high homocysteine level, folic acid deficiency, the impact of genetics should not be ignored.
In this study, we will investigate whether there are specific genotypes which may predict the incidence of (1)enalapril-induced dry cough in Chinese and (2)first stroke in hypertensive patients taking enalapril or enalapril-folic acid therapy, so as to provide a basis for developing guidelines on precision medication in enalapril therapy apply to Chinese population.
Chinese Patients:In accordance with anti-hypertension indications of enalapril
Exclusion Criteria:
Detection of genotype will be carried out through next generation sequencing, distinguish wild genotype of enalapril
Genetic: detection of genotype
Detection of genotype will be carried out through next generation sequencing, distinguish mutant genotype of enalapril
Genetic: detection of genotype
detection of genotype by next generation sequencing
Incidence of dry cough
Time frame: At 2 years
First Incidence of stroke
Time frame: At 2 years
Genotype detected by next generation sequencing
Collect blood specimen before enalapril administration, then detect genotype of enalapril by next generation sequencing.
Time frame: pre-dose of enalapril or enalapril-folic acid (Baseline)
This study is status unknown, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.
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Cui Yimin