An interventional study of Lingual Muscle Training in Glycogen Storage Disease, sponsored by Duke University. Completed at 1 site in United States. Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2021-07-28.
Sponsored by Duke University · Not applicable, Interventional, and Treatment
Among 16 studies in Glycogen Storage Disease with a site in United States — 5 open to participants now, 6 under way, none of them phase 3. Glycogen Storage Disease · United States.
Among the 16 studies in Glycogen Storage Disease with a site in United States, this one is the only one that started in 2018, is one of 2 with no phase, and was the 9th registered.
36 studies on the registry are indexed under Glycogen Storage Disease; 13 are open to participants now.
Browse Glycogen Storage Disease studies →5 of the 16 studies in Glycogen Storage Disease with a site in United States are open now. Recruiting first, the newest first:
Atrium Therapeutics · Sites in United States
Ages 18–65
AskBio Inc · Sites in United States
Ages 18–65
Shionogi · Sites in United States, Belgium, Denmark and 6 more countries
Ages 18+
Duke University · Sites in United States
Ages 0–90
Sanford Health · Sites in United States
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 9 Glycogen Storage Disease studies recruiting now, 4 set no upper age limit and 4 stop at 75 or younger; 6 take children under 18; 2 take healthy volunteers.
This study: 12 Years and older · all sexes · no healthy volunteers.
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16 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 5 · Phase 2 6
First in 1992; this study’s year is marked. 1 started in 2018.
This study's enrollment of 5 is below the median of 16 across 18 interventional studies indexed under Glycogen Storage Disease.
Median enrollment 14 across the 8 interventional studies, 45 across the 8 observational. Of the 10 that completed or were terminated, 1 (10%) have results posted.
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8 of 16 have an industry lead sponsor. The 10 most frequent:
Duke University is the lead sponsor of 2,063 studies on the registry; 272 are open to participants now.
Of its 204 completed or terminated interventional studies of FDA-regulated products, 167 (82%) have results posted.
Duke University has 3 studies filed under Glycogen Storage Disease — fewer than ten, so there is no comparison to draw.
2 of the studies in Glycogen Storage Disease with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05095727ModernaTX, Inc.A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a) | 2026-11-30 |
| NCT07123155ShionogiStudy of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD) | 2027-08-08 |
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Among the 16 studies in Glycogen Storage Disease with a site in United States, from their registry updates:
Nothing recorded among them since 2026-09-25.
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This study is being done to test the effects of Lingual Muscle Therapy (LMT) in patients with Late-Onset Pompe Disease (LOPD) who have tongue weakness. The results of this study will help design future research studies about LMT in LOPD.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Other: Lingual Muscle Training
Lingual Muscle Training using the Iowa Oral Performance Instrument (OIPI) device
Safety of lingual muscle training
Safety measured by pain rating scale
Time frame: 13 weeks
Feasibility of lingual muscle training as measured by questionnaires
Time frame: 13 weeks
Change in lingual strength
Change from pre-test to post-test
Time frame: baseline, 13 weeks
Plan to share: No
No publications or documents are linked to this record.
Ran from Mar 2018 to primary completion in Apr 2020, 25 months.
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This study is completed, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.
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