A Phase 2 interventional study of Nitroglycerin patch 5mg and placebo in Hemorrhagic Shock, sponsored by Assiut University. Status unknown at 2 sites in Egypt. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2017-08-01.
Sponsored by Assiut University · Phase 2, Interventional, and Treatment
Hemorrhagic shock is a pathologic state in which intravascular volume and oxygen delivery are impaired. During circulatory failure associated with hypovolemia and low cardiac output, redistribution of blood flow caused by increased vasoconstriction results in decreased perfusion of the skin.
Skin temperature and capillary refill time has been advocated as a measure of peripheral perfusion.
Perfusion index (PI) is a non-invasive numerical value of peripheral perfusion obtained from pulse oximetry, it is an indicator of the pulse strength at the sensor site. The PI's values range from 0.2% for very weak pulse to 20% for extremely strong pulse according to patient's physiological conditions and monitoring sites.
Large increases in lactate (i.e. > 5 mmol/L) usually only occur due to hypoperfusion or muscle activity such as exercise or seizures.
This study will investigate the role of nitroglycerine patch in improving the peripheral perfusion in poly traumatized patient with hemorrhagic shock for the first time.
916 studies on the registry are indexed under Shock; 176 are open to participants now.
This study's planned enrollment of 100 is above the median of 77 across 540 interventional studies indexed under Shock.
Browse Shock studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
nitroglycerin patch 5 mg applied to front of chest in each patient at time of admission once.
Drug: Nitroglycerin patch 5mg
no drug given to the patients in control group
Other: placebo
application of the nitroglycerin patch 5 mg to each patient in nitroglycerin group
Also known as: nitroglycerin
no drug given to the control group
increase of perfusion index PI measured by pulse oximeter
nitroglycerin increases the perfusion index in patients with hemorrhagic shock more than in control group without use of nitroglycerin
Time frame: 48hours
Plan to share: Yes
This study is status unknown, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.
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Assiut University