An interventional study of Silver Diamine Fluoride and Distilled Water in Dental Caries and Dental Caries of Root Surface, sponsored by The University of Hong Kong. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-06-14.
Sponsored by The University of Hong Kong · Not applicable, Interventional, and Prevention
This study measures and compares the effect of silver diamine fluoride (SDF) on caries increment in removable partial denture wearers. Half of the participants will SDF and while the other half will receive placebo.
Removable partial dentures are commonly constructed to replace missing teeth. It is observed that removable partial denture wearers are susceptible to dental caries.
The mode of action of silver diamine fluoride on caries prevention is dual: fluoride ions interact synergistically with silver to react with hydroxyapatite to form fluorapatite, and silver is bactericidal by reacting with the thiol groups of the amino and nucleic acids that halt the metabolic and reproductive functions of the cariogenic bacteria.
Exclusion Criteria:
38% silver diamine fluoride solution (Saforide, Toyo Seiyaku Kasei Co. Ltd., Osaka, Japan) is professionally applied to exposed coronal and root surfaces of all teeth every 6 months for 36 months.
Drug: Silver Diamine Fluoride
Distilled water is professionally applied to exposed coronal and root surfaces of all teeth every 6 months for 36 months.
Drug: Distilled Water
Silver diamine fluoride solution is applied to the dried and exposed coronal and root surfaces of all teeth by means of a disposable microbrush.
Also known as: Saforide
Distilled water is applied to the dried and exposed coronal and root surfaces of all teeth by means of a disposable microbrush.
Caries increment
New and recurrent caries lesions are recorded according to the International Caries Detection and Assessment System (ICDAS). Molars and premolars are considered to have 5 coronal surfaces, whereas canines and incisors are considered to have 4. The cleaned and dried teeth are recorded as sound, sealed, restored, crowned, or missing. Each coronal tooth surface is classified using a 7-point ordinal scale ranging from sound to extensive cavitation using a WHO probe. The same procedure is repeated for all root surfaces. Coronal and root surface caries increments are calculated by comparing the baseline and follow-up observations for each tooth surface.
Time frame: 36 months
Prevalence of oral colonization of oral yeasts
The prevalence of oral yeast in oral rinse and dental plaque is counted. Prevalence is expressed as percentage of the participants.
Time frame: 36 months
Colonization of oral yeasts in oral rinse
The count of oral yeasts in oral rinse is recorded. The count of oral yeast in oral rinse is expressed as colony-forming unit (cfu)/ml.
Time frame: 36 months
Colonization of oral yeasts in dental plaque
The count of oral yeasts in dental plaque is recorded. The count of oral yeast in dental plaque is expressed as cfu/g.
Time frame: 36 months
Prevalence of oral colonization of Streptococcus mutans (S. mutans)
The prevalence S. mutans in stimulated whole saliva (SWS) and dental plaque is counted. Prevalence is expressed as percentage of the participants.
Time frame: 36 months
Colonization of S. mutans in saliva
The count of S. mutans in SWS is recorded. The count of S. mutans in SWS is expressed as cfu/ml.
Time frame: 36 months
Colonization of S. mutans in dental plaque
The count of S. mutans dental plaque is recorded. The count of S. mutans in dental plaque is expressed as cfu/g.
Time frame: 36 months
Prevalence of oral colonization of lactobacilli
The prevalence of lactobacilli in SWS and dental plaque is counted. Prevalence is expressed as percentage of the participants.
Time frame: 36 months
Colonization of lactobacilli in saliva
The count of lactobacilli in SWS is recorded. The count of lactobacilli in SWS is expressed as cfu/ml.
Time frame: 36 months
Colonization of lactobacilli in dental plaque
The count of lactobacilli in dental plaque is recorded. The count of lactobacilli in dental plaque is expressed as cfu/g.
Time frame: 36 months
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.
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The University of Hong Kong