An observational study in Breast Cancer Female and Thyroid Gland, sponsored by The First Affiliated Hospital of Bengbu Medical University. Recruiting at 1 site in China. Open to female participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by The First Affiliated Hospital of Bengbu Medical University · Observational
Breast cancer is one of the most common cancers in China. Even though advances in the field of breast cancer therapeutics, chemotherapy remains the mainstay therapeutic modality. The cytotoxic therapies are generally associated with some immediate or otherwise delayed side effects, such as adverse effects on gastrointestinal, hepatic, renal and hematological systems. The effect of chemotherapy on endocrine system, however, is comparatively less envisaged. Several epidemiological studies show a positive association between plasma thyroid hormones levels and breast cancer risk. Thyroid dysfunction is emerging as a variably common endocrine toxicity of several anticancer drugs. Due to the scarcity of data on the functioning of thyroid gland during chemotherapy in a large scale group, the present study was aimed to investigate the incidence of thyroid abnormity in Chinese women with newly diagnosed breast cancer, and also the effects of chemotherapy on thyroid gland functions or structure in these breast cancer patients undergoing at least four cycles of chemotherapy.
Newly diagnosed female breast cancer
Exclusion Criteria:
Newly diagnosed breast cancer patients undergoing at least four cycles of chemotherapy
Drug: Chemotherapy
Healthy Volunteers
Newly diagnosed breast cancer patients undergoing at least four cycles of chemotherapy.
Number of participants newly diagnosed with breast cancer
Rate of thyroid function (measured by chemiluminescence methods) or structure (measured by ultrasonic imaging) abnormity at the time of diagnosis and during chemotherapeutic period will be reported.
Time frame: 1 week around the indicated detection point
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The First Affiliated Hospital of Bengbu Medical University