An observational study in Stroke, Brain Ischemia and Adipokines, sponsored by Xi'an No.3 Hospital. Recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2017-04-24.
Sponsored by Xi'an No.3 Hospital · Observational
This observational study aims to research whether there is a relationship between omentin and ischemic stroke on the aspects of incidence, severity, and recovery etc.
To study the possible relationship between omentin and ischemic stroke, we intend to recruit the newly found acute ischemic stroke patients and patients without any stroke history and analysis the difference of plasma omentin level and the ITLN, which is the gene symbol of omentin.
the study population is from primary care clinic, physical examination center, and social volunteers.
Exclusion Criteria:
For ischemic stroke group
patients without any history of stroke
patients with an episode of neurological dysfunction caused by focal cerebral, spinal, or retinal infarction within 72 hours.
the odds ratio of omentin plasma concentration between cases and controls
The circulation level of omentin will be assessed in cases and controls. Then the odds ratio will be statically analysed to detect whether omentin is asociated with ischemic stroke on protein level.
Time frame: up to 3 years
the frequency difference of single nucleotide polymorphism(SNP) of omentin in the enrolled subjects
The SNP will be analysed in the recruited subjects. And the the frequency difference will be calculated to explore if any SNP is related to ischemic stroke.
Time frame: up to 3 years
the NIHSS assessed for functional outcome of stroke
NIHSS wil be used to assess neurological status at baseline or the point of stroke, the point of out-patient, 3 month, 6 month, 1 year, 2 year and the 3 year.
Time frame: up to 3 years
the modified Rankin Scale assessed for functional disability
Th functional disability will be assessed using the modified Rankin Scale at the time of baseline, out-patient, 3rd month, 6th month, 1st year, 2nd year and the 3rd year after enrollment.
Time frame: up to 3 years
the Barthel index assessed for functional independence in activities
The Barthel index at the point of baseline, out-patient, 3rd month, 6th month, 1st year, 2nd year and the 3rd year after enrollment will be assessed for the functional independence in activities.
Time frame: up to 3 years
the number of all cause death
The number of all cause of death will be recorded in both groups.
Time frame: up to 3 years
the number of re-stroke in case group
Recurrent of stroke will be monitored through out in case group.
Time frame: up to 3 years
Plan to share: Yes
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Xi'an No.3 Hospital