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CompletedNCT03102905REPLIPOUpdated Jun 12, 2026

Prevalence of Replication of Human Herpes Virus 6 (HHV6) in Blood and Skin During Exanthemia, in Patients With Hemopathy. Is There a Correlation With the Etiology of the Exanthema?

An observational study in HHV6, Exanthema and Hemopathy, sponsored by Centre Hospitalier Universitaire, Amiens. Completed at 1 site in France. Per ClinicalTrials.gov, last updated 2026-06-12.

Sponsored by Centre Hospitalier Universitaire, Amiens · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
37
Sex
All
01

Study summary

To look for the replication of HHV6 by PCR in the skin, in these patients with haemopathies presenting an exanthema. This will make it possible to evaluate the prevalence of the positivity of this PCR in the skin. Then the investigator can investigate whether there is an association between the positivity of HHV6 PCR in the blood and / or skin and the viral etiology of the exanthema. If this association exists, it will make it possible to improve the diagnosis in the context of the exanthema and thus to improve the therapeutic management of these patients.

02

Conditions studied

  • HHV6
  • Exanthema
  • Hemopathy

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03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Any patient hospitalized in the Clinical Hematology and Cellular Therapy department of the CHU Amiens-Picardie between 01/01/2011 and 31/01/2016

Inclusion criteria

  • Supported for any type of hemopathy.
  • Allograft, autografted or ungrafted haematopoietic stem cells
  • Having presented an exanthema during hospitalization, for which a cutaneous biopsy had been performed
  • Having had a blood test of the HHV6 virus by PCR at least within the previous 40 days or following the rash.
  • Age greater than or equal to 18 years
  • Patient informed of the protocol by post, not having refused within one month of sending the said courier.

Exclusion criteria

Exclusion Criteria:

  • Patient who refused the search.
  • Patient whose HHV6 PCR in the blood was carried out at a distance of more than 40 days from the skin biopsy.
04

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
37 participants (actual)
Patient registry
No

Interventions

  • OtherMeasurement of the prevalence of the positivity of cutaneous HHV6 quantitative PCR in the cohort studied.

    To evaluate the prevalence of the positivity of HHV6 PCR in the skin, during the exanthema in patients hospitalized for haemopathy.

05

What researchers measure

Primary outcomes

  1. Measurement of the prevalence of the positivity of cutaneous HHV6 quantitative PCR in the cohort studied.

    Time frame: 1 day

06

Study locations

1 site
  • CHU Amiens Picardie
    Amiens, Picardie 80054, France
07

Registry details

Key details

Study ID
NCT03102905
Lead sponsor
Centre Hospitalier Universitaire, Amiens
Responsible party
Sponsor
First posted
Apr 6, 2017
Start date
Dec 12, 2016
Primary completion
Sep 28, 2018
Completion
Sep 28, 2018
Last update
Jun 12, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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