An observational study in Langerhans Cell Histiocytoses, sponsored by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau. Status unknown at 1 site in Spain. Per ClinicalTrials.gov, last updated 2020-08-18.
Sponsored by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Observational
Very recent studies indicate that a high percentage of HCL, about 50%, have mutations in the B-RAF oncogene. The development of ultrasensitive methodologies capable of identifying these mutations in bronchoalveolar lavage will represent a significant advance in the diagnosis and treatment of these patients. An undetermined percentage of HCL does not present mutations in B-RAF. Consequently, the deep genetic analysis, through the use of techniques of massive sequencing, can favor the identification of new alterations that contribute to the development of the disease.
We hypothesized that patients with HCL may present a different inflammatory state to healthy subjects or smokers, allowing us to identify new biomarkers.
The main objective of this study is to expand the genetic and pathophysiological knowledge of this disease. For this, the following points will be developed:
80 studies on the registry are indexed under Histiocytosis, Langerhans-Cell; 22 are open to participants now.
This study's planned enrollment of 20 is below the median of 97 across 14 observational studies indexed under Histiocytosis, Langerhans-Cell.
Browse Histiocytosis, Langerhans-Cell studies →Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau is the lead sponsor of 335 studies on the registry; 64 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients diagnosed with Langerhans cell histiocytosis
Exclusion criteria
Number of participants with mutations in the B-RAF oncogene in Langerhans histiocytosis
Time frame: Baseline
This study is status unknown, as verified in Aug 2020. You cannot join it, but the record below documents what was studied.
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Histiocytosis, Langerhans-Cell→
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau