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CompletedNCT03082326Updated Aug 1, 2017

The CCUS Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value

An observational study in Shock, sponsored by West China Hospital. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-08-01.

Sponsored by West China Hospital · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
181
Ages
18 Years and older
Sex
All
01

Study summary

Shock is a common condition in critical care unit (ICU). It is extremely important that the patient accepts early goal-directed therapy (EGDT) treatment in the early stage of shock. However, several studies failed to demonstrate that the well used variables such as CVP and others could direct to a better treatment. In recent years, critical care ultrasound (CCUS) has been respected as a reliable noninvasive tool and widely used in ICU practice. With CCUS the investigators can accurately acquired the detailed information of the characteristic of the hemodynamics and lung pathology (the systole and diastole function, volume status, valve insufficiency, lung, edema, consolidation, and pleural effusion, etc.). To the investigators knowledge, there is no study investigating the epidemic of such ultrasonic variables and its value to predict to outcome. The aim of this study is to investigate the epidemic and the prognostic value of CCUS Based Characteristic of Hemodynamic and Lung pathology in Early Stage of Shock in patients admitted in ICU.

Read the detailed description

Adult patients who admitted to the intensive care unit of West China hospital of sichuan university with shock from April 2016 to April 2017 enrolled.

02

Conditions studied

  • Shock

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Keywords

  • shock
  • critical care ultrasound
  • hemodynamics
  • lung pathology
  • epidemic
  • prognosis
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In context

Shock

916 studies on the registry are indexed under Shock; 176 are open to participants now.

This study's enrollment of 181 is above the median of 91 across 346 observational studies indexed under Shock.

Browse Shock studies →

Lead sponsor

West China Hospital is the lead sponsor of 483 studies on the registry; 240 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Shock patients with 6 hours admitted in ICU in west china hospital of sichuan university.

Inclusion criteria

  1. SBP\<90 mm Hg or MAP \<70 mm Hg or SBP decrease >40mmHg or need vasoactive drugs;
  2. Skin that is cold and clammy, capillary refill time >4.5s, urine output of \<0.5ml/Kg.hr and lactate>2mmol/L;
  3. SHOCK presented within 6 hr.

Exclusion criteria

Exclusion Criteria:

  1. \<18 years old;
  2. Pregnancy;
  3. Patient or family member refuse to be enrolled.
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Study design

Observational model
Other
Time perspective
Prospective
Enrollment
181 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. all cause mortality

    Time frame: 28 days

Secondary outcomes

  1. length of mechanical ventilation

    Time frame: through study completion, an average of 28 days

  2. ICU length of stay

    Time frame: through study completion, an average of 28 days

  3. hospital length of stay

    Time frame: through study completion, an average of 28 days

07

Study locations

1 site
  • West China Hospital,Sichuan University
    Chengde, Sichuan 610041, China
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References and documents

Publications

  • Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001 Nov 8;345(19):1368-77. doi: 10.1056/NEJMoa010307. PubMed 11794169 ↗
  • Vincent JL, De Backer D. Circulatory shock. N Engl J Med. 2014 Feb 6;370(6):583. doi: 10.1056/NEJMc1314999. No abstract available. PubMed 24499231 ↗
  • Seif D, Perera P, Mailhot T, Riley D, Mandavia D. Bedside ultrasound in resuscitation and the rapid ultrasound in shock protocol. Crit Care Res Pract. 2012;2012:503254. doi: 10.1155/2012/503254. Epub 2012 Oct 24. PubMed 23133747 ↗
  • Levitov A, Frankel HL, Blaivas M, Kirkpatrick AW, Su E, Evans D, Summerfield DT, Slonim A, Breitkreutz R, Price S, McLaughlin M, Marik PE, Elbarbary M. Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part II: Cardiac Ultrasonography. Crit Care Med. 2016 Jun;44(6):1206-27. doi: 10.1097/CCM.0000000000001847. PubMed 27182849 ↗
  • Guerin L, Vieillard-Baron A. The Use of Ultrasound in Caring for Patients with Sepsis. Clin Chest Med. 2016 Jun;37(2):299-307. doi: 10.1016/j.ccm.2016.01.005. Epub 2016 Mar 3. PubMed 27229646 ↗
  • Wang H, Cui N, Su L, Long Y, Wang X, Zhou X, Chai W, Liu D. Prognostic value of extravascular lung water and its potential role in guiding fluid therapy in septic shock after initial resuscitation. J Crit Care. 2016 Jun;33:106-13. doi: 10.1016/j.jcrc.2016.02.011. Epub 2016 Feb 24. PubMed 27021852 ↗
  • Zhou R, Zou T, Yin W, Wang X, Kang Y; Chinese Critical Ultrasound Study Group (CCUSG). Functional mitral regurgitation combined with increased early diastolic transmitral velocity to early mitral annulus diastolic velocity ratio is associated with a poor prognosis in patients with shock. Chin Med J (Engl). 2021 Sep 15;134(19):2299-2305. doi: 10.1097/CM9.0000000000001756. PubMed 34629416 ↗
  • Zou T, Yin W, Li Y, Deng L, Zhou R, Wang X, Chao Y, Zhang L, Kang Y; Chinese Critical Ultrasound Study Group (CCUSG). Hemodynamics in Shock Patients Assessed by Critical Care Ultrasound and Its Relationship to Outcome: A Prospective Study. Biomed Res Int. 2020 Sep 15;2020:5175393. doi: 10.1155/2020/5175393. eCollection 2020. PubMed 33015171 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 1, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03082326
Lead sponsor
West China Hospital
Responsible party
tongjuan ZOU (Doctor, West China Hospital) — Principal investigator
First posted
Mar 17, 2017
Start date
Apr 5, 2016
Primary completion
Jun 6, 2017
Completion
Jun 6, 2017
Last update
Aug 1, 2017

Study contacts

yan kang, doctor
study chair · West China Hospital

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.

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