An interventional study of e-cig with nicotine and e-cig without nicotine in Nicotine Dependence, sponsored by University of California, Los Angeles. Completed at 1 site in United States. Open to participants aged 21 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-10-04.
Sponsored by University of California, Los Angeles · Not applicable, Interventional, and Basic science
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, nicotine inhaler, and sham-control on endothelial function, oxidative stress and sympathetic nerve activity
Participants will have an acute exposure on 4 occasions1) e-cigarette with nicotine, 2) e-cigarette without nicotine, 3) nicotine inhaler, 4) sham control and undergo ECG recording for heart rate variability, endothelial function measurement using ultrasound ("FMD") and blood tests for oxidative stress markers.
968 studies on the registry are indexed under Tobacco Use Disorder; 126 are open to participants now.
This study's enrollment of 148 is above the median of 89 across 851 interventional studies indexed under Tobacco Use Disorder.
Browse Tobacco Use Disorder studies →University of California, Los Angeles is the lead sponsor of 1,142 studies on the registry; 192 are open to participants now.
Of its 91 completed or terminated interventional studies of FDA-regulated products, 66 (73%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
One time exposure to e-cig with nicotine
Other: e-cig with nicotine
One time exposure to e-cig without nicotine
Other: e-cig without nicotine
One time exposure to nicotine inhaler
Other: nicotine inhaler
Use an empty e-cigarette
Other: sham control
use an e-cig with nicotine for 30 minutes
use an e-cig without nicotine for 30 minutes
use a nicotine inhaler for 30 minutes
use an empty e-cigarette for 30 minutes
Flow Mediated dilatation (FMD)
FMD is a measure of endothelial function
Time frame: 10 minutes after exposure
Heart rate variability (HRV)
HRV is a measure of cardiac sympathetic tone
Time frame: 10 minutes after exposure
Paraoxonase (PON)
PON is a measure of oxidative stress
Time frame: ~30 minutes after exposure
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.
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University of California, Los Angeles