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RecruitingNCT03072537CrescNetUpdated Nov 7, 2023

CrescNet - Growth Monitoring Network

An observational study in Obesity, Child Development and Growth Disorders, sponsored by University of Leipzig. Recruiting at 1 site in Germany. Open to participants aged Up to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-07.

Sponsored by University of Leipzig · Observational

From the registry’s dates

  • Started Jan 1998; still recruiting 28 years 9 months later.
Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
1,000,000
Ages
Up to 18 Years
Sex
All
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Study summary

CrescNet is a network of primary care physicians and pediatricians (n=219) and endocrinological treatment centers (n=33), established in Leipzig in 1998, whose aim is to improve the early detection of growth disorders. Secondary to this clinical aim, epidemiological analyses, for example on secular trends of growth data of children, are performed.

Read the detailed description

Pediatricians participating in CrescNet provide pseudononymized data on patients' height, weight, and head circumferences to the CrescNet registry. Growth data are evaluated by automatized filter algorithms and by a pediatric endocrinologist. CrescNet does not have access to patients or personal patient data. Each participating pediatrician receives a quarterly screening report with recommendations for the work-up of children with abnormal growth or abnormal development of weight or body mass index.

The data registry is used for scientific purposes.The collection of data from healthy children allows the generation of evidence based statements about prevalence rates of growth disorders and also about the rates in disorders of weight development. For this, data are provided completely anonymized without allowing conclusions on personal patient data.

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Conditions studied

  • Obesity
  • Child Development
  • Growth Disorders

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Keywords

  • growth
  • BMI
  • obesity
  • childhood
  • adolescence
  • development
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In context

Growth Disorders

167 studies on the registry are indexed under Growth Disorders; 24 are open to participants now.

This study's planned enrollment of 1,000,000 is above the median of 205 across 67 observational studies indexed under Growth Disorders.

Browse Growth Disorders studies →

Lead sponsor

University of Leipzig is the lead sponsor of 147 studies on the registry; 24 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 18 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

479, 576 boys with 2,570, 041 visits und 453,510 girls with 2,427,350 visits from screening and/or consulting visits at 1 of the 435 participating German pediatricians.

Eligibility criteria

Inclusion Criteria: Population based sample with inclusion of any patient seen by primary care or institutional physician/pediatrician, regardless of the objective for the visit (well child visits, acute visits or special requests)

Exclusion Criteria: none

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Study design

Observational model
Other
Time perspective
Prospective
Enrollment
1,000,000 participants (estimated)
Target follow-up
18 Years
Patient registry
Yes
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What researchers measure

Primary outcomes

  1. growth disorders

    Early detection of growth disorders in childhood and adolescent development. For this, not only absolute data but also growth velocity data are evaluated.

    Time frame: 18 years

  2. obesity

    detection of critical age periods for the development of obesity. For this, not only absolute data but also growth velocity data are evaluated.

    Time frame: 18 years

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Study locations

1 of 1 sites recruiting
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References and documents

Publications

  • Herget S, Markert J, Petroff D, Gausche R, Grimm A, Hilbert A, Kiess W, Bluher S. Psychosocial Well-Being of Adolescents Before and After a 1-Year Telephone-Based Adiposity Prevention Study for Families. J Adolesc Health. 2015 Sep;57(3):351-4. doi: 10.1016/j.jadohealth.2015.05.014. PubMed 26299563 ↗
  • Wagner IV, Paetzold C, Gausche R, Vogel M, Koerner A, Thiery J, Arsene CG, Henrion A, Guettler B, Keller E, Kiess W, Pfaeffle R, Kratzsch J. Clinical evidence-based cutoff limits for GH stimulation tests in children with a backup of results with reference to mass spectrometry. Eur J Endocrinol. 2014 Sep;171(3):389-97. doi: 10.1530/EJE-14-0165. Epub 2014 Jun 24. PubMed 24966174 ↗
  • Markert J, Alff F, Zschaler S, Gausche R, Kiess W, Bluher S. Prevention of childhood obesity: recruiting strategies via local paediatricians and study protocol for a telephone-based counselling programme. Obes Res Clin Pract. 2013 Dec;7(6):e476-86. doi: 10.1016/j.orcp.2012.07.008. PubMed 24308890 ↗
  • Alff F, Markert J, Zschaler S, Gausche R, Kiess W, Bluher S. Reasons for (non)participating in a telephone-based intervention program for families with overweight children. PLoS One. 2012;7(4):e34580. doi: 10.1371/journal.pone.0034580. Epub 2012 Apr 3. PubMed 22509327 ↗
  • Keller A, Klossek A, Gausche R, Hoepffner W, Kiess W, Keller E. [Selective primary obesity prevention in children]. Dtsch Med Wochenschr. 2009 Jan;134(1-2):13-8. doi: 10.1055/s-0028-1105883. Epub 2008 Dec 17. German. PubMed 19090446 ↗
  • Keller E, Gausche R, Meigen C, Keller A, Burmeister J, Kiess W. Auxological computer based network for early detection of disorders of growth and weight attainment. J Pediatr Endocrinol Metab. 2002 Feb;15(2):149-56. doi: 10.1515/jpem.2002.15.2.149. PubMed 11874179 ↗
  • Kiess W, Gausche R, Keller A, Burmeister J, Willgerodt H, Keller E. Computer-guided, population-based screening system for growth disorders (CrescNet) and on-line generation of normative data for growth and development. Horm Res. 2001;56 Suppl 1:59-66. doi: 10.1159/000048137. PubMed 11786688 ↗
  • Keller E, Burmeister J, Gausche R, Keller A, Hermanussen M, Kiess W. [Model program for the early detection and optimal treatment of disorders of growth and physical development using a medical competence netwok]. Z Arztl Fortbild Qualitatssich. 2000 Sep;94(8):695-8. German. PubMed 11084726 ↗
  • Kapellen TM, Gausche R, Dost A, Wiegand S, Flechtner-Mors M, Keller E, Kiess W, Holl RW; DPV-Science-Initiative of the German Competence Network Diabetes and the German Competence Network Obesity (Consortium LARGE). Children and adolescents with type 1 diabetes in Germany are more overweight than healthy controls: results comparing DPV database and CrescNet database. J Pediatr Endocrinol Metab. 2014 Mar;27(3-4):209-14. doi: 10.1515/jpem-2013-0381. PubMed 24197766 ↗
  • Miersch A, Vogel M, Gausche R, Siekmeyer W, Pfaffle R, Dittrich K, Kiess W. Blood pressure tracking in children and adolescents. Pediatr Nephrol. 2013 Dec;28(12):2351-9. doi: 10.1007/s00467-013-2596-3. PubMed 23959541 ↗
  • Hoepffner W, Pfaffle R, Gausche R, Meigen C, Keller E. Early detection of growth disorders with the CrescNet system at the Leipzig treatment center. Dtsch Arztebl Int. 2011 Feb;108(8):123-8. doi: 10.3238/arztebl.2011.0123. Epub 2011 Feb 25. PubMed 21403802 ↗
  • Bluher S, Meigen C, Gausche R, Keller E, Pfaffle R, Sabin M, Werther G, Odeh R, Kiess W. Age-specific stabilization in obesity prevalence in German children: a cross-sectional study from 1999 to 2008. Int J Pediatr Obes. 2011 Jun;6(2-2):e199-206. doi: 10.3109/17477166.2010.526305. Epub 2010 Nov 23. PubMed 21091288 ↗
  • Heger S, Korner A, Meigen C, Gausche R, Keller A, Keller E, Kiess W. Impact of weight status on the onset and parameters of puberty: analysis of three representative cohorts from central Europe. J Pediatr Endocrinol Metab. 2008 Sep;21(9):865-77. doi: 10.1515/JPEM.2008.21.9.865. PubMed 18924580 ↗
  • Meigen C, Keller A, Gausche R, Kromeyer-Hauschild K, Bluher S, Kiess W, Keller E. Secular trends in body mass index in German children and adolescents: a cross-sectional data analysis via CrescNet between 1999 and 2006. Metabolism. 2008 Jul;57(7):934-9. doi: 10.1016/j.metabol.2008.02.008. PubMed 18555834 ↗
  • Korner A, Kratzsch J, Gausche R, Schaab M, Erbs S, Kiess W. New predictors of the metabolic syndrome in children--role of adipocytokines. Pediatr Res. 2007 Jun;61(6):640-5. doi: 10.1203/01.pdr.0000262638.48304.ef. PubMed 17426657 ↗
  • Beger C, Merker A, Mumm R, Gausche R. Growth prediction of small for gestational age infants within the first weeks after birth. Anthropol Anz. 2018 Jun 11;74(5):377-382. doi: 10.1127/anthranz/2018/0820. Epub 2018 Feb 20. PubMed 29461564 ↗
  • Kess A, Spielau U, Beger C, Gausche R, Vogel M, Lipek T, Korner A, Pfaffle R, Kiess W. Further stabilization and even decrease in the prevalence rates of overweight and obesity in German children and adolescents from 2005 to 2015: a cross-sectional and trend analysis. Public Health Nutr. 2017 Dec;20(17):3075-3083. doi: 10.1017/S1368980017002257. Epub 2017 Sep 21. PubMed 28931448 ↗
  • Thiele AG, Gausche R, Lindenberg C, Beger C, Arelin M, Rohde C, Mutze U, Weigel JF, Mohnike K, Baerwald C, Scholz M, Kiess W, Pfaffle R, Beblo S. Growth and Final Height Among Children With Phenylketonuria. Pediatrics. 2017 Nov;140(5):e20170015. doi: 10.1542/peds.2017-0015. PubMed 29089407 ↗
  • Vogel M, Geserick M, Gausche R, Beger C, Poulain T, Meigen C, Korner A, Keller E, Kiess W, Pfaffle R. Age- and weight group-specific weight gain patterns in children and adolescents during the 15 years before and during the COVID-19 pandemic. Int J Obes (Lond). 2022 Jan;46(1):144-152. doi: 10.1038/s41366-021-00968-2. Epub 2021 Sep 23. PubMed 34556774 ↗
  • Geserick M, Vogel M, Gausche R, Lipek T, Spielau U, Keller E, Pfaffle R, Kiess W, Korner A. Acceleration of BMI in Early Childhood and Risk of Sustained Obesity. N Engl J Med. 2018 Oct 4;379(14):1303-1312. doi: 10.1056/NEJMoa1803527. PubMed 30281992 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 7, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03072537
Lead sponsor
University of Leipzig
Responsible party
Antje Koerner, Prof. Dr. med. (Prof. Dr. med. Antje Körner, University of Leipzig) — Principal investigator
First posted
Mar 7, 2017
Start date
Jan 1, 1998
Primary completion
Jan 1, 2028 (estimated)
Completion
Jan 1, 2028 (estimated)
Last update
Nov 7, 2023

Study contacts

Roland W Pfäffle, MD
Contact
roland.pfaeffle@medizin.uni-leipzig.de
Ruth Gausche
Contact
gausche@crescnet.org
Roland W Pfäffle, MD
principal investigator · University of Leipzig

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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