An observational study in Pediatric Cataract, Congenital Cataract and Traumatic Cataract, sponsored by Evidence Based Cataract Study Group. Recruiting at 1 site in China. Open to participants aged 2 Months to 20 Years. Per ClinicalTrials.gov, last updated 2024-09-27.
Sponsored by Evidence Based Cataract Study Group · Observational
The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.
1,701 studies on the registry are indexed under Cataract; 230 are open to participants now.
This study's planned enrollment of 10,000 is above the median of 81 across 484 observational studies indexed under Cataract.
Browse Cataract studies →Evidence Based Cataract Study Group is the lead sponsor of 6 studies on the registry; 2 are open to participants now.
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Medical centre: Eye and ENT Hospital of Fudan University
Exclusion Criteria:
Cataract patients diagnosed with congenital cataract.
Procedure: intraocular lens implantation
Cataract patients diagnosed with traumatic cataract.
Procedure: intraocular lens implantation
1）Pediatric cataract patients with intraocular lens implantation and those without intraocular lens implantation；2）Traumatic cataract patients with intraocular lens implantation and those without intraocular lens implantation
Differences in the visual outcomes of pediatric cataract patients.
Visual outcomes are evaluated including visual acuity with or without correction, refractive changes, intraocular pressure, fundus function, fixation type, vision development, growth of axial length, contrast sensitivity and other visual outcome measurements.
Time frame: Follow-up until ten years after surgery.
Genetic diversity based on biospecimen samples of pediatric cataract patients.
Sequencing of genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of congenital cataract patients, compared to traumatic cataract patients.Samples of blood, aqueous humor, anterior capsular membranes and lens tissues were applied for the genetic analysis.
Time frame: Analyzed within six months after surgery.
Differences in the clinical phenotypes of pediatric cataract patients.
Cataract type and severity of ametropic cataract patients are evaluated and images are captured before receiving the cataract surgery.
Time frame: Evaluated before receiving the cataract surgery.
Plan to share: Undecided
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Evidence Based Cataract Study Group