An observational study in Hypocalcemia and Vitamin D Deficiency, sponsored by Hillel Yaffe Medical Center. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-02-24.
Sponsored by Hillel Yaffe Medical Center · Observational
Post-operative hypocalcaemia following total thyroidectomy is a well-known complication and becoming a major area of research.
Many factors are assumed to increase the incidence of post-thyroidectomy hypocalcaemia, but the impact of vitamin D deficiency remains uncertain.
Since results so far were inconclusive, the goal in this study is to significantly determine the relation between those two factors.
This study is the first to deal with this issue through patients who underwent total thyroidectomy that was performed by the same surgeon and the same surgical technique.
A retrospective evaluation study of patients who underwent total thyroidectomy at the head and neck unit of the Otorhinolaryngology department at our institution between January 2013 and October 2016.
A total number of 60 patients underwent total thyroidectomy with available vitamin D levels before surgery, as well as pre and post-operative PTH and calcium levels.
Pre-operative vitamin D and PTH levels were checked within a maximum of one month duration before surgery.
All patients were operated by the same surgeon -Dr. Galit Avior-, with the same surgical technique.
The study involves access to the patients files and admission reports. In addition the investigators would like to be able to call the patients in order to ask them whether Vitamin D deficiency was corrected or not before their surgery, and If it was corrected then when exactly.
Background Post-operative hypocalcaemia following total thyroidectomy is a well-known complication and becoming a major area of research.
Many factors are assumed to increase the incidence of post-thyroidectomy hypocalcaemia, but the impact of vitamin D deficiency remains uncertain.
Vitamin D deficiency is known to be one of the most common medical conditions in the world.. Serum calcium is mainly regulated by parathyroid hormone (PTH) and vitamin D, therefore demonstration of a correlation between preoperative vitamin D levels and the occurrence of post thyroidectomy hypocalcaemia may reveal an easily correctable factor.
Recently, few studies have investigated whether preoperative vitamin D levels have any effect on post thyroidectomy hypocalcaemia. Some of them showed that patients with vitamin D deficiency were more likely to develop postoperative hypocalcaemia. In addition a significant decrease in postoperative hypocalcemia was shown in patients who received supplementation of vitamin D regardless of their vitamin D status, while others found no relationship between preoperative vitamin D concentrations and postoperative hypocalcaemia .
Since results so far were inconclusive, the goal in this study is to significantly determine the relation between those two factors.
This study is the first to deal with this issue through patients who underwent total thyroidectomy that was performed by the same surgeon and the same surgical technique.
Study objective
Study design A retrospective evaluation study of patients who underwent total thyroidectomy at the head and neck unit of the Otorhinolaryngology department at our institution between January 2013 and October 2016.
A total number of 60 patients underwent total thyroidectomy with available vitamin D levels before surgery, as well as pre and post-operative PTH and calcium levels.
Pre-operative vitamin D and PTH levels were checked within a maximum of one month duration before surgery.
All patients were operated by the same surgeon -Dr. Galit Avior-, with the same surgical technique.
Methods:
The study involves access to the patients files and admission reports. In addition the investigators would like to be able to call the patients in order to ask them whether Vitamin D deficiency was corrected or not before their surgery, and If it was corrected then when exactly.
772 studies on the registry are indexed under Vitamin D Deficiency; 61 are open to participants now.
This study's planned enrollment of 60 is below the median of 138 across 183 observational studies indexed under Vitamin D Deficiency.
Browse Vitamin D Deficiency studies →Hillel Yaffe Medical Center is the lead sponsor of 301 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
A total number of 60 patients underwent total thyroidectomy with available vitamin D levels before surgery, as well as pre and post-operative PTH and calcium levels.
Pre-operative vitamin D and PTH levels were checked within a maximum of one month duration before surgery.
Exclusion Criteria:
patients who underwent total thyroidectomy with available vitamin D levels before surgery, as well as pre and post-operative PTH and calcium levels.
Other: vitamin D levels and Calcium levels examination
observational
Vitamin D levels
ng/ml
Time frame: pre- operative vitamin D levels 1 month prior to surgery
Calcium levels
mg/dl
Time frame: post operative Ca levels at the day of the surgery
Calcium levels
mg/dl
Time frame: post operative Ca levels 1 day after the surgery
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.
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Hillel Yaffe Medical Center