An observational study in Genetic Predisposition to Disease, Hyperglycemia and Intensive Care Unit Syndrome, sponsored by University Hospital, Lille. Completed at 5 sites in France. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-05-14.
Sponsored by University Hospital, Lille · Observational
This study evaluates the link between genetic polymorphisms as r7903146, rs12255372 of TCF7L2 gene and the risk of developing hyperglycemia during Intensive care unit stay
241 studies on the registry are indexed under Genetic Predisposition to Disease; 95 are open to participants now.
This study's enrollment of 994 is above the median of 500 across 154 observational studies indexed under Genetic Predisposition to Disease.
Browse Genetic Predisposition to Disease studies →University Hospital, Lille is the lead sponsor of 631 studies on the registry; 142 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients admitted in ICU > 48h with at least one organ dysfunction
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
patients with a least one organ dysfunction
Genetic: genetic analysis · Biological: blood and stools samples
value of the odds ratio associated with the relationship between a polymorphism TCF7L2 gene and the occurrence of hyperglycemia
find a link between genetic polymorphism of TCF7L2 and the risk of developing hyperglycemia in intensive care patients with a least one organ dysfunction. the hyperglycemia is defined fasting glucose\> 1.26 g / l twice or need for treatment with insulin)
Time frame: one year after inclusion
Changes in inflammatory markers
Time frame: one year after inclusion
Changes in serum lipid profile
Changes in cholesterol total, LDL cholesterol, HDL cholesterol and triglycerides
Time frame: one year after inclusion
Changes in liver enzymes
Changes in total alanine transaminase (ALT) total gamma-GT total aspartate transaminase (AST)
Time frame: one year after inclusion
Insulin Resistance (HOMA)
Calculated using the updated homeostasis model assessment (HOMA) calculator.Higher numbers indicate higher insulin resistance. There are no established cutoffs indicating impaired resistance.
Time frame: one year after inclusion
Blood samples collection
the blood samples collection will created for next research Both on diabetes and / or insulin resistance as its determinisms, at the ICU patient
Time frame: 5 years
Number of patients with genotype TCF7L2 by PCR
the prevalence of TCF7L2, in the intensive care patient or not glycemic control, and compared to the values found in the general population. the TCF7L2 genes will be evaluated by the Taqman method (7900HT Fast Real-Time PCR System-Applied BioSystem).
Time frame: 5 years
Plan to share: No
This study is completed, as verified in May 2018. You cannot join it, but the record below documents what was studied.
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