An observational study in Severe Malnutrition, sponsored by Peking University Third Hospital. Status unknown at 1 site in China. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2017-02-16.
Sponsored by Peking University Third Hospital · Observational
Severe malnutrition can be seen as a low BMI, great weight loss, and even low levels of micronutrients. Current studies on severe malnutrition are mainly in patient with anorexia nervosa. The refeeding phase of these high-risk patients bears a further threat to health and potentially fatal complications (such as refeeding syndrome, infection and severe arrhythmia). The objective of this study is to investigate complications due to refeeding of patients with severe malnutrition, as well as their mortality rate, establish and modify the guideline for management of severe malnutrition in Peking University Third Hospital.
Severe malnutrition can be seen as a low BMI, great weight loss, and even low levels of micronutrients. Current studies on severe malnutrition are mainly in patient with anorexia nervosa. The refeeding phase of these high-risk patients bears a further threat to health and potentially fatal complications (such as refeeding syndrome, infection and severe arrhythmia).
Intensive care unit of Peking University Third Hospital (PUTH) has treated several patients with severe malnutrition successfully since 2008. Most of these patients had a BMI \< 10 (kg/m2) at admission. After admission, a multidisciplinary team, consisting of specialists in the field of intensive care, pharmacy, psychology, and physical therapy assessed all patients. Most of the treatment has been regarded successful with a significant BMI gain and little in-hospital mortality. Based on long-term clinical experience, as well as on evidence-based literature, PUTH nutrition group developed a guideline version 1.0 for the treatment of severe malnutrition in August, 2015.
The objective of this study is to investigate complications due to refeeding of patients with severe malnutrition, as well as their mortality rate, establish and modify the guideline for management of severe malnutrition in PUTH.
This is a single-center, ambispective cohort study. Patients who meet the inclusion and exclusion criteria will be included in our registry. As a non-intervention study, these information as below will be collected: reason for admission, relevant medical history, basic demographic characteristics,anthropometric and clinical data, specific nutrition support regimen and outcomes.
1,587 studies on the registry are indexed under Malnutrition; 237 are open to participants now.
This study's planned enrollment of 80 is below the median of 203 across 388 observational studies indexed under Malnutrition.
Browse Malnutrition studies →Peking University Third Hospital is the lead sponsor of 735 studies on the registry; 262 are open to participants now.
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The patients with severe malnutrition (BMI \< 13 kg/m2), admitted to PUTH from JAN 2008 are involved in this study.
Exclusion Criteria:
Patients with severe malnutrition (BMI\<13 kg/m2), admitted to Peking University Third Hospital from JAN 2008 are involved in this study. After admission, a multidisciplinary team, consisting of specialists in the field of intensive care, pharmacy, psychology, and physical therapy assessed all patients. Management and treatment of these patients are in accordance with guideline for the management of severe malnutrition in PUTH.
Other: management of severe malnutrition
multidisciplinary assessment; guideline for the management of severe malnutrition in PUTH
28-day change of BMI
Time frame: from admission to 28-day/discharge, an average of length of ICU stay is 28-day
All-cause 28-day mortality
Time frame: from admission to 28-day
The rate of infection in ICU
Time frame: from admission to discharge of ICU, an average of length of ICU stay is 28-day
The rate of refeeding syndrome
Time frame: from admission to discharge, an average of length of ICU stay is 28-day
The rate of complications
Time frame: from admission to discharge, an average of length of ICU stay is 28-day
Length of ICU stay
Time frame: from admission to discharge of ICU, an average of length of ICU stay is 28-day
Cost-effectiveness of treatment
The outcome is the incremental cost of preventing one treatment failure of refeeding syndrome, infection, and all-cause mortality.
Time frame: from admission to discharge of ICU (an average of length of ICU stay is 28-day), from admission to discharge of hospital (an average of length of hospital stay is three-month)
All-cause mortality within six month
Time frame: from admission to six month
Length of hospital stay
Time frame: from admission to discharge of hospital, an average of length of hospital stay is three-month
Plan to share: No
This study is status unknown, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.
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Peking University Third Hospital