An Early Phase 1 interventional study of Midazolam in Midazolam Overdose, sponsored by ART Fertility Clinics LLC. Terminated at 1 site in United Arab Emirates. Open to female participants aged 18 Years to 38 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-05-06.
Sponsored by ART Fertility Clinics LLC · Early Phase 1, Interventional, and Treatment
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics.
The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature oocyte and therefore develop into a potential embryo to be analyzed.
The correlation of Midazolam levels in follicular fluid and euploid status of the embryos is worth exploring as no data exists that suggests any influence on the quality of the embryos from using this substance for IVF since its earliest days. Measuring time lapsed from injection to first oocyte retrieval as well as time lapsed in between first and last oocyte retrieved will grand insight into the rise of levels of Midazolam inside the follicular fluid, correlated with the chromosomal status and the morphokinetic development of the euploid embryos.
139 studies on the registry are indexed under Drug Overdose; 24 are open to participants now.
This study's enrollment of 30 is below the median of 100 across 98 interventional studies indexed under Drug Overdose.
Browse Drug Overdose studies →ART Fertility Clinics LLC is the lead sponsor of 51 studies on the registry; 20 are open to participants now.
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Exclusion Criteria:
Sedation will be established by administering 100mcs of Fentanyl, and 1-1.5mg/kg of body weight of Propofol.
Sedation will be established by administering Midazolam 1mg, 100mcs of Fentanyl, and 0.5-1mg/kg of body weight of Propofol. Further boluses of Propofol will be given according to the need of the patient and time consumed for oocyte retrieval.
Drug: Midazolam
The impact of Midazolam levels in follicular fluid.
Midazolam values measured by the time from the injection of Midazolam to the oocyte aspiration .
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics.
Time frame: 6-12 months
Plan to share: No
This study is terminated, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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ART Fertility Clinics LLC