ClinicalTrials.gg
RecruitingNCT05969574Updated Jun 25, 2026

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

An observational study in Infertility, Female, Miscarriage and Miscarriage, Recurrent, sponsored by ART Fertility Clinics LLC. Recruiting at 3 sites in United Arab Emirates. Open to female participants. Per ClinicalTrials.gov, last updated 2026-06-25.

Sponsored by ART Fertility Clinics LLC · Observational

From the registry’s dates

  • Started Sep 2023; still recruiting 3 years 2 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
2,059
Sex
Female
01

Study summary

This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.

Read the detailed description

By investigating the prevalence of low ovarian reserve (LOR) in populations with specific reproductive histories (such as recurrent pregnancy loss, G0, and ectopic pregnancy), as well as the aneuploidy rates of embryos produced with Preimplantation Genetic Testing for Aneuploidies (PGT-A), Investigators can better understand how LOR impacts fertility outcomes in these populations. This information can be used to inform clinical decision-making, such as whether participants with LOR should consider alternative or whether they would benefit from additional interventions to improve ovarian function.

Ultimately, by improving our understanding of how LOR impacts fertility outcomes in specific populations, Investigators can help to improve the overall success rates of infertility treatment, reduce anxiety, and distress, and help participants achieve goals of becoming parents.

02

Conditions studied

  • Infertility, Female
  • Miscarriage
  • Miscarriage, Recurrent
  • IVF

Keywords

  • miscarriage
  • infertility
  • IVF
03

In context

Infertility, Female

552 studies on the registry are indexed under Infertility, Female; 137 are open to participants now.

This study's planned enrollment of 2,059 is above the median of 161 across 162 observational studies indexed under Infertility, Female.

Browse Infertility, Female studies →

Lead sponsor

ART Fertility Clinics LLC is the lead sponsor of 51 studies on the registry; 20 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Female
Sampling method
Non-probability sample

Study population

All participants who visit ART Fertility clinics in Abu Dhabi, Al Ain and Dubai for first consultation

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

1. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai)

Exclusion criteria

Exclusion Criteria:

  1. Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT))
  2. Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation
  3. Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound
  4. History of ovarian surgery, chemotherapy, or radiation therapy
  5. Known genetic disorder or chromosomal abnormality
  6. >40Kg/m2
  7. Currently using hormonal or hormone replacement therapy
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

Contraception

Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.

Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
2,059 participants (estimated)
Patient registry
No

Groups and cohorts

  • AMH <1.3, at least 1 pregnancy or at least 1 miscarriage

    Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.

    Diagnostic Test: Transvaginal ultrasound · Diagnostic Test: Blood test AMH

  • AMH <1.3, at least 1 pregnancy and no miscarriage

    Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.

    Diagnostic Test: Transvaginal ultrasound · Diagnostic Test: Blood test AMH

  • AMH ≥ 1.3, at least 1 pregnancy or at least 1 miscarriage

    Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.ons.

    Diagnostic Test: Transvaginal ultrasound · Diagnostic Test: Blood test AMH

  • AMH ≥1.3, at least 1 pregnancy and no miscarriage

    Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.

    Diagnostic Test: Transvaginal ultrasound · Diagnostic Test: Blood test AMH

Interventions

  • Diagnostic testTransvaginal ultrasound

    Transvaginal ultrasound for antral follicle count (AFC) performed on the day of first consultation

  • Diagnostic testBlood test AMH

    Measurement of AMH performed on the day of first consultation

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What researchers measure

Primary outcomes

  1. AMH

    Anti-Müllerian Hormone Test

    Time frame: 1 day

  2. AFC

    Antral follicle count

    Time frame: 1 day

07

Study locations

3 of 3 sites recruiting
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References and documents

Publications

  • ESHRE working group on Ectopic Pregnancy; Kirk E, Ankum P, Jakab A, Le Clef N, Ludwin A, Small R, Tellum T, Toyli M, Van den Bosch T, Jurkovic D. Terminology for describing normally sited and ectopic pregnancies on ultrasound: ESHRE recommendations for good practice. Hum Reprod Open. 2020 Dec 16;2020(4):hoaa055. doi: 10.1093/hropen/hoaa055. eCollection 2020. PubMed 33354626 ↗
  • Tan J, Luo L, Jiang J, Yan N, Wang Q. Decreased Ovarian Reserves With an Increasing Number of Previous Early Miscarriages: A Retrospective Analysis. Front Endocrinol (Lausanne). 2022 Jun 10;13:859332. doi: 10.3389/fendo.2022.859332. eCollection 2022. PubMed 35757430 ↗
  • Bliddal S, Feldt-Rasmussen U, Forman JL, Hilsted LM, Larsen EC, Christiansen OB, Nielsen CH, Kolte AM, Nielsen HS. Anti-Mullerian hormone and live birth in unexplained recurrent pregnancy loss. Reprod Biomed Online. 2023 Jun;46(6):995-1003. doi: 10.1016/j.rbmo.2023.01.023. Epub 2023 Feb 3. PubMed 37055255 ↗
  • Stirrat GM. Recurrent miscarriage. II: Clinical associations, causes, and management. Lancet. 1990 Sep 22;336(8717):728-33. doi: 10.1016/0140-6736(90)92215-4. PubMed 1975901 ↗
  • Wang X, Chen C, Wang L, Chen D, Guang W, French J. Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study. Fertil Steril. 2003 Mar;79(3):577-84. doi: 10.1016/s0015-0282(02)04694-0. PubMed 12620443 ↗
  • Coomarasamy A, Dhillon-Smith RK, Papadopoulou A, Al-Memar M, Brewin J, Abrahams VM, Maheshwari A, Christiansen OB, Stephenson MD, Goddijn M, Oladapo OT, Wijeyaratne CN, Bick D, Shehata H, Small R, Bennett PR, Regan L, Rai R, Bourne T, Kaur R, Pickering O, Brosens JJ, Devall AJ, Gallos ID, Quenby S. Recurrent miscarriage: evidence to accelerate action. Lancet. 2021 May 1;397(10285):1675-1682. doi: 10.1016/S0140-6736(21)00681-4. Epub 2021 Apr 27. PubMed 33915096 ↗
  • Bunnewell SJ, Honess ER, Karia AM, Keay SD, Al Wattar BH, Quenby S. Diminished ovarian reserve in recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril. 2020 Apr;113(4):818-827.e3. doi: 10.1016/j.fertnstert.2019.11.014. Epub 2020 Mar 4. PubMed 32145928 ↗
  • Seifer DB. Connecting the dots between oocyte quantity and quality in diminished ovarian reserve. Fertil Steril. 2021 Apr;115(4):890. doi: 10.1016/j.fertnstert.2021.01.020. Epub 2021 Mar 6. No abstract available. PubMed 33750616 ↗
  • Tarasconi B, Tadros T, Ayoubi JM, Belloc S, de Ziegler D, Fanchin R. Serum antimullerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer. Fertil Steril. 2017 Sep;108(3):518-524. doi: 10.1016/j.fertnstert.2017.07.001. PubMed 28865551 ↗
  • Lyttle Schumacher BM, Jukic AMZ, Steiner AZ. Antimullerian hormone as a risk factor for miscarriage in naturally conceived pregnancies. Fertil Steril. 2018 Jun;109(6):1065-1071.e1. doi: 10.1016/j.fertnstert.2018.01.039. Epub 2018 Jun 2. PubMed 29871793 ↗
  • Atasever M, Soyman Z, Demirel E, Gencdal S, Kelekci S. Diminished ovarian reserve: is it a neglected cause in the assessment of recurrent miscarriage? A cohort study. Fertil Steril. 2016 May;105(5):1236-1240. doi: 10.1016/j.fertnstert.2016.01.001. Epub 2016 Jan 21. PubMed 26806685 ↗
  • Leclercq E, de Saint Martin L, Bohec C, Le Martelot MT, Roche S, Alavi Z, Mottier D, Pasquier E. Blood anti-Mullerian hormone is a possible determinant of recurrent early miscarriage, yet not conclusive in predicting a further miscarriage. Reprod Biomed Online. 2019 Aug;39(2):304-311. doi: 10.1016/j.rbmo.2019.04.004. Epub 2019 Apr 12. PubMed 31186176 ↗
  • Jaswa EG, McCulloch CE, Simbulan R, Cedars MI, Rosen MP. Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity. Fertil Steril. 2021 Apr;115(4):966-973. doi: 10.1016/j.fertnstert.2020.10.051. Epub 2021 Feb 12. PubMed 33583594 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05969574
Lead sponsor
ART Fertility Clinics LLC
Responsible party
Laura Melado (IVF Specialist, ART Fertility Clinics LLC) — Principal investigator
First posted
Aug 1, 2023
Start date
Sep 9, 2023
Primary completion
Dec 31, 2026 (estimated)
Completion
Dec 31, 2026 (estimated)
Last update
Jun 25, 2026

Study contacts

Barbara Lawrenz, PhD
Contact
barbara.lawrenz@artfertilityclinics.com
+971 800 337845489
Jonalyn Edades, RN
Contact
jonalyn.edades@artfertilityclinics.com
+971 800 337845489
Laura Melado, PhD
principal investigator · ART Fertility Clinics LLC

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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