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CompletedNCT03032939Updated Jan 26, 2017

The Effect of Tracheal Intubation on AC and DC Components of a Photoplethysmograph

An observational study in Anesthesia Intubation Complication, sponsored by University of California, San Francisco. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-01-26.

Sponsored by University of California, San Francisco · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
35
Ages
18 Years and older
Sex
All
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Study summary

Intraoperative stress responses (vasoconstriction and changes in heart rate) and postoperative pain can be monitored using photoplethysmography (PPG). PPG measures changes in tissue volume noninvasively. Therefore it can measure acute changes in arterial diameter (vasoconstriction). PPG signal has two components, AC and DC. Effects of noxious stimuli-induced stress responses (vasoconstriction) have not been studied on the DC component of PPG. The aim of this study was to investigate the effect of a known noxious stimulus (endotracheal intubation) on both the AC and DC components of PPG.

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Conditions studied

  • Anesthesia Intubation Complication
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In context

Lead sponsor

University of California, San Francisco is the lead sponsor of 2,164 studies on the registry; 368 are open to participants now.

Of its 267 completed or terminated interventional studies of FDA-regulated products, 199 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Elective, healthy surgical patients over 18 yrs of age

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Elective surgery
  • General endotracheal anesthesia
  • Over 18 years of age
  • Healthy

Exclusion criteria

Exclusion Criteria:

  • Vascular disease
  • Liver or kidney disease
  • Overweight
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
35 participants (actual)
Patient registry
No

Interventions

  • Procedureendotracheal intubation

    standard endotracheal intubation of surgical patients after induction of anesthesia

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What researchers measure

Primary outcomes

  1. Photoplethysmography

    changes in AC and DC components of photoplethysmography

    Time frame: within 60 seconds of intubation

Secondary outcomes

  1. Pulse rate

    Pulse rate from photoplethysmograph

    Time frame: within 60 seconds of intubation

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Talke P. The Effect of Tracheal Intubation-Induced Autonomic Response on Photoplethysmography. Anesthesiol Res Pract. 2017;2017:7646541. doi: 10.1155/2017/7646541. Epub 2017 Apr 2. PubMed 28469670 ↗

Individual participant data

Plan to share: No — only a unique study number such as, IP01, that is unrelated to any patient identifiers will be used

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 26, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03032939
Responsible party
Pekka Talke (Professor of Anesthesia, University of California, San Francisco) — Principal investigator
First posted
Jan 26, 2017
Start date
Dec 18, 2007
Primary completion
Jan 30, 2012
Completion
Jan 30, 2015
Last update
Jan 26, 2017

Study contacts

Pekka O Talke, MD
principal investigator · University of California, San Francisco

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.

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