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CompletedNCT03019679Updated Feb 1, 2021

Serum Endocan Levels in Polycystic Ovary Syndrome

An observational study in Polycystic Ovary Syndrome, sponsored by Tokat Gaziosmanpasa University. Completed at 1 site in Turkey. Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-02-01.

Sponsored by Tokat Gaziosmanpasa University · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
175
Ages
18 Years to 45 Years
Sex
Female
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Study summary

In this study the investigators aimed to investigate whether there is a relation between polycystic ovary syndrome and serum endocan levels.

Read the detailed description

Polycystic ovary syndrome is a disorder which is associated with insulin resistance, diabetes, obesity, and cardiovascular disease. Endothelial dysfunction, which is known to be an early marker of atherosclerosis, has also been shown to have an association with poycystic ovary syndrome. In this study the investigators aimed to investigate whether there is a relation between polycystic ovary syndrome and serum endocan levels. For this purpose the investigators designed a prospective study including two groups. The diagnosis of polycystic ovary syndrome was made in the presence of ;oligo- and/or anovulation,clinical hyperandrogenism and polycystic ovaries. Clinical hyperandrogenism was defined by the presence of hirsutism , acne, or the presence of androgenic alopecia, body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters. The two groups are compared considering their serum endocan levels,follicle stimulating hormone (FSH), luteinizing hormone (LH), Dihydroepiandesterone sulphate (DHEAS), total testesterone (TT), estradiol (E2) and thyroid stimulating hormone (TSH), fasting blood glucose, triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein, and C-reactive protein (CRP) levels.

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Conditions studied

  • Polycystic Ovary Syndrome
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In context

Polycystic Ovary Syndrome

944 studies on the registry are indexed under Polycystic Ovary Syndrome; 174 are open to participants now.

This study's enrollment of 175 is above the median of 118 across 223 observational studies indexed under Polycystic Ovary Syndrome.

Browse Polycystic Ovary Syndrome studies →

Lead sponsor

Tokat Gaziosmanpasa University is the lead sponsor of 164 studies on the registry; 38 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

84 women with PCOS and 84 healty women as control group.

Inclusion criteria

  • 18 to 45 years
  • Patients diagnosed with PCOS according to Rotterdam criteris (for the study group)
  • Patients without PCOS and menstrual irregularities (for the control group)
  • Absence of significant abnormalities on physical examination except hirsutism
  • No lipid lowering, hypoglycemic, antihypertensive or hormone replacement therapy
  • Normal thyroid function and prolactin level
  • Absence of history or evidence of metabolic, cardiovascular, respiratory or hepatic disease

Exclusion criteria

Exclusion Criteria:

  • Pregnant
  • Ovarian tumors
  • Endocrine diseases (Cushing disease, 21-Hydroxylase enzyme deficiency, thyroid dysfunction,hyperprolactinemia,diabetes)
  • Chronic diseases (renal insufficiency, cardiovascular, hepatic disease)
  • Oral contraceptive use, anti-androgenic,glucocorticoid, anti-hypertansive- anti-diabetic drug use
  • Smoking or alcohol use
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
175 participants (actual)
Patient registry
No
Biospecimen retention
None retained

Groups and cohorts

  • Study group

    Patients with polycystic ovary syndrome

  • Control group

    Patients without polycyctic ovary syndrome

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What researchers measure

Primary outcomes

  1. Serum endocan level and its relationship with Polycystic Ovary Syndrome

    Time frame: 3 months

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Study locations

1 site
  • Gaziosmanpasa University
    Tokat, 60000, Turkey
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 1, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03019679
Lead sponsor
Tokat Gaziosmanpasa University
Responsible party
İlhan Bahri Delibas (Assistant Professor, Tokat Gaziosmanpasa University) — Principal investigator
First posted
Jan 12, 2017
Start date
Jan 2017
Primary completion
Apr 2017
Completion
Apr 2017
Last update
Feb 1, 2021

Study contacts

Ilhan B Delibas, M.D.
principal investigator · Gaziosmanpasa University Department of Obstetrics and Gynecology
Esra Laloglu, M.D.
study chair · Erzurum Halk Saglıgı Laboratuvarı

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.

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