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CompletedNCT02984280Updated May 4, 2017

Specific Respiratory Infections as Triggers of Acute Medical Events

An observational study in Influenza, Human, Respiratory Syncytial Virus Infections and Parainfluenza, sponsored by University College, London. Completed at 1 site in United Kingdom. Open to participants aged 45 Years and older. Per ClinicalTrials.gov, last updated 2017-05-04.

Sponsored by University College, London · Observational

Study type
Observational
Model
Ecologic or community
Time perspective
Retrospective
Enrollment
787,000
Ages
45 Years and older
Sex
All
01

Study summary

This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and Hospital Episode Statistics.

Read the detailed description

We will conduct a time series study correlating anonymised population level data on all samples from NHS laboratories testing positive for six common respiratory viruses with admissions to NHS hospitals in England for a range of cardiac and vascular outcomes over the time period 01/01/2004 to 31/12/2014. This will involve generating Poisson regression models controlling for factors such as seasonal and long-term trends, environmental temperature and humidity.

This study is funded by an Academy of Medical Sciences Starter Grant for Clinical Lecturers.

02

Conditions studied

  • Influenza, Human
  • Respiratory Syncytial Virus Infections
  • Parainfluenza
  • Rhinovirus
  • Adenovirus
  • Human Metapneumovirus Pneumonia
  • Cardiovascular Diseases
03

In context

Infections

6,687 studies on the registry are indexed under Infections; 807 are open to participants now.

This study's enrollment of 787,000 is above the median of 240 across 2,136 observational studies indexed under Infections.

Browse Infections studies →

Lead sponsor

University College, London is the lead sponsor of 632 studies on the registry; 145 are open to participants now.

Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Adult population of England who have received NHS care during the study period.

Inclusion criteria

  • Any individual with a record of an eligible outcome (ICD-10 coded hospitalisation for myocardial infarction or stroke) within the study period aged 45+ years
  • Any individual with a record of an eligible exposure (laboratory-confirmed respiratory virus) within the study period at any age

Exclusion criteria

Exclusion Criteria:

  • Outcome events occurring in people aged \<45 years
05

Study design

Observational model
Ecologic or community
Time perspective
Retrospective
Enrollment
787,000 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Acute myocardial infarction

    ICD-10 coded

    Time frame: 01/01/2004 to 31/12/2014

  2. Stroke

    ICD-10 coded

    Time frame: 01/01/2004 to 31/12/2014

07

Study locations

1 site
  • University College London (UCL)
    London, NW1 2DA, United Kingdom
08

References and documents

Publications

  • Blackburn R, Zhao H, Pebody R, Hayward A, Warren-Gash C. Laboratory-Confirmed Respiratory Infections as Predictors of Hospital Admission for Myocardial Infarction and Stroke: Time-Series Analysis of English Data for 2004-2015. Clin Infect Dis. 2018 Jun 18;67(1):8-17. doi: 10.1093/cid/cix1144. PubMed 29324996 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02984280
Lead sponsor
University College, London
Collaborators
Public Health England
Responsible party
Sponsor
First posted
Dec 6, 2016
Start date
Sep 2016
Primary completion
Mar 2017
Completion
Mar 2017
Last update
May 4, 2017

Study contacts

Charlotte MJ Warren-Gash, MRCP PhD
principal investigator · UCL

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.

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