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Status unknownNCT02969330Updated Nov 21, 2016

Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli

An interventional study of Stimulator and Glucose in Brain Activity and Glucose Control, sponsored by Tel Aviv University. Status unknown. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-11-21.

Sponsored by Tel Aviv University · Not applicable, Interventional, and Basic science

The sponsor has not verified this record recently (last verified Nov 2016), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.

02

Conditions studied

  • Brain Activity
  • Glucose Control
03

In context

Lead sponsor

Tel Aviv University is the lead sponsor of 100 studies on the registry; 26 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Healthy volunteers
  • Age 18-65 years old.
  • Body mass index 18 to 25 kg/m2
  • Capable of giving informed consent

Exclusion criteria

Exclusion Criteria:

  • Pregnancy, or nursing
  • Permanent pacemakers
  • Metal prosthesis
  • Skin disease
  • Claustrophobia
  • History of neurological disorders
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    Glucose

    Glucose ingestion

    Dietary Supplement: Glucose

  • Active comparator
    PES

    Single session of short PES treatment before glucose ingestion.

    Device: Stimulator · Dietary Supplement: Glucose

Interventions

  • DeviceStimulator
  • Dietary supplementGlucose

    300ml tap water with 75g glucose

06

What researchers measure

Primary outcomes

  1. Changes in postprandial cerebral blood flow (fMRI) and cerebral diffusivity (fDWI) in response to glucose ingestion.

    Time frame: changes from baseline to 30 minutes after glucose ingestion

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 21, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02969330
Lead sponsor
Tel Aviv University
Collaborators
Sheba Medical Center
Responsible party
Uri Nevo (PhD, Tel Aviv University) — Principal investigator
First posted
Nov 21, 2016
Start date
Dec 2016
Primary completion
Jan 2018 (estimated)
Last update
Nov 21, 2016

Study contacts

Uri Nevo, PhD
Contact
nevouri@post.tau.ac.il
972-3-6407542

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.

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