An observational study in Resting Metabolic Rate and Energy Metabolism, sponsored by Tel Aviv University. Not yet recruiting. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-05.
Sponsored by Tel Aviv University · Observational
This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions. Participants will undergo RMR assessments three times per week using whole-room indirect calorimetry.
The study will quantify the magnitude of physiological variability in RMR, distinguish true biological variation from measurement error, and estimate the minimal detectable change required to identify meaningful metabolic adaptations.
Resting metabolic rate (RMR) is a major component of total daily energy expenditure and is widely used in metabolic research. However, most studies rely on single or infrequent measurements, assuming RMR is stable within individuals.
Emerging evidence suggests that RMR exhibits measurable within-individual variability, but the temporal structure and magnitude of this variability remain poorly characterized.
This study will implement a high-frequency repeated-measures design, with RMR measured three times per week over 12 weeks using whole-room indirect calorimetry under standardized conditions. This approach will allow detailed characterization of short-term variability and provide estimates for within-subject variability, measurement error, and minimal detectable change.
The findings will inform interpretation of longitudinal metabolic studies and improve study design in future research.
Healthy adult men and women from the community, aged 18-65 years, who are clinically healthy and able to participate in repeated metabolic measurements under standardized laboratory conditions.
Exclusion Criteria:
Healthy adult participants undergoing repeated measurements of resting metabolic rate (RMR) three times per week over a 12-week period under standardized conditions. No intervention is applied.
Other: Repeated Measurement of Resting Metabolic Rate
Repeated assessment of resting metabolic rate under standardized conditions; no intervention is administered.
Within-Individual Variability in Resting Metabolic Rate (RMR)
Within-individual variability in resting metabolic rate (RMR) assessed using repeated measurements under standardized conditions. Variability will be quantified using mean, standard deviation (SD), and coefficient of variation (CV%) across repeated measurements.
Time frame: 12 weeks
Minimal Detectable Change (MDC) in RMR
The minimal detectable change in resting metabolic rate required to distinguish true physiological change from measurement variability.
Time frame: 12 weeks
Between-Individual Variability in RMR
Assessment of variability in resting metabolic rate between participants based on repeated measurements.
Time frame: 12 weeks
Temporal Trends in RMR
Assessment of systematic changes in resting metabolic rate over time using repeated measurements across the study period.
Time frame: 12 weeks
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Tel Aviv University