An interventional study of Licorice and Sugar water in Pain, Postoperative and Surgery, Oral, sponsored by Medical University of Vienna. Completed at 1 site in Austria. Open to participants aged 12 Years to 99 Years. Per ClinicalTrials.gov, last updated 2023-09-05.
Sponsored by Medical University of Vienna · Not applicable, Interventional, and Treatment
Our primary aim is to determine whether licorice gargling provides meaningful analgesia after oral surgery. Specifically, we propose to test the primary hypothesis that gargling with licorice solution reduces pain after oral surgery more than gargling with sugar water. Because effective analgesia can reduce pain and/or opioid consumption, we will jointly evaluate verbal response pain scores and overall morphine consumption considering licorice to be beneficial only if it proves non-inferior on both measures and superior on at least one.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 127 is above the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
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Exclusion Criteria:
Licorice gargle
Other: Licorice
Sugar gargle
Other: Sugar water
ExtractumLiquiritiaeFluidum, 1 g diluted in 30cc water, gargle the solution for 60 seconds without swallowing it starting preoperatively, 3 times a day until post-operative day 3
Also known as: Extractum Liquiritiae Fluidum
Sugar gargle: Sirupus Simplex (sugar 5 g) diluted in 30cc water, gargle the solution for 60 seconds without swallowing it starting preoperatively, 3 times a day until post-operative day 3
joint - pain scores and opiate consumption in Post Anesthesia Care Unit (PACU)
A joint outcome of average pain score and total opioid consumption between the end of surgery and the first two postoperative hours. Joint hypothesis testing will be used, meaning that Licorice gargling will be deemed better than sugar-water only if found noninferior on both opioid consumption and pain score and superior on at least one of the two.
Time frame: first 2 postoperative hours
joint - pain scores and opiate consumption on day of surgery
Postoperative pain intensity and opioid consumption between the end of surgery and the first postoperative morning. Joint hypothesis testing will be used, meaning that Licorice gargling will be deemed better than sugar-water only if found noninferior on both opioid consumption and pain score and superior on at least one of the two.
Time frame: from end of surgery until the morning of Post-Operative Day (POD) 1
joint - pain scores and analgesic consumption
pain intensity and total analgesics (metamizole or mefenamic acid) consumption in the first three days after surgery. Joint hypothesis testing will be used, meaning that Licorice gargling will be deemed better than sugar-water only if found noninferior on both opioid consumption and pain score and superior on at least one of the two.
Time frame: from surgery conclusion to Post-Operative Day (POD) 3
postoperative coughing
incidence and intensity of postoperative coughing between surgery and the first two hours in the PACU
Time frame: first 2 postoperative hours
Plan to share: No
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This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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Medical University of Vienna