An observational study in Postoperative Cognitive Dysfunction, sponsored by Central South University. Status unknown at 1 site in China. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2016-11-16.
Sponsored by Central South University · Observational
Postoperative cognitive dysfunction (POCD) is a subtle cognitive dysfunction, especially postoperative memory impairment lasting for weeks or months. The underlying pathophysiological mechanism of POCD remain unclear. The aim of this study is to explore the epigenetic changes during perioperative period and its correlation with POCD in surgical patients.
The incidence of postoperative cognitive dysfunction (POCD) in elderly patients ranges widely from 16% to 21% and is associated with adverse outcomes. The exact cause of POCD remains unknown. Extensive studies report that epigenetic modification, including the alteration of DNA methylation and chromatin structure, plays an important part in the regulation of memory and learning. The present study thus hypothesize that epigenetic modification may increase the risk for POCD. The present study will enrolled the elderly patients (aged≥65) and young and middle-aged patents (aged 20-50) who are planning to undergo elective noncardiac surgery under general anesthesia. Perioperative clinical characteristics of all patients will be recorded. Participants enrolled will be evaluated for POCD with Mini-Mental State Examination (MMSE) on preoperative day, postoperative days 1. Postoperative pain will be evaluated by the numerical rating scale (NRS). The patients' blood will be collected in the morning on the day before surgery and after surgery when they recover consciousness for the detection of concentration of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) by enzyme-linked immunosorbent assays (ELISA).
The present study may help to find whether epigenetic changes will occur after surgical and anesthesia stress and will be an important factor for POCD in elderly patients.
264 studies on the registry are indexed under Postoperative Cognitive Complications; 54 are open to participants now.
This study's planned enrollment of 100 is close to the median of 100 across 113 observational studies indexed under Postoperative Cognitive Complications.
Browse Postoperative Cognitive Complications studies →Central South University is the lead sponsor of 126 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
central south university,xiangya 2nd hospital,general surgery department
Inclusion Criteria:
•ASA Grade I to III Age >65 BMI 18-28kg/m2 Patients undergoing abdominal surgery,orthopedic surgery and spinal surgery
Exclusion Criteria:
Exclusion Criteria:
Patients who don't develop POCD after surgery.
Patients who develop POCD after surgery.
Correlation of epigenetic changes with POCD
The present study will examine concentration of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in whole blood by enzyme-linked immunosorbent assays (ELISA) to determine the correlation of epigenetic changes with POCD in surgical patients.
Time frame: 24 hours
The effects of surgical and anesthesia stress on epigenetic changes
Numerous studies have reported that both acute and chronic stress can cause epigenetic modification. Surgical stress also belongs to acute stress during perioperative period. Thus the present study will compare concentration of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) before and after operation to determine whether surgical and anesthesia stress will induce epigenetic changes.
Time frame: 24 hours
Plan to share: No
This study is status unknown, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.
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Postoperative Cognitive Complications→
Central South University