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CompletedNCT02928653LCSUpdated Mar 21, 2019

Beverage Consumption and Fine Motor Control

An interventional study of Beverage in Body Weight, sponsored by Purdue University. Completed at 1 site in United States. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-03-21.

Sponsored by Purdue University · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
187
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

The aim of this study will be to compare the effects of daily consumption of aspartame, rebaudioside a, saccharin, sucralose, and sucrose on body weight and composition in a standardized protocol. The investigators hypothesize that individual low calorie sweeteners (consumed in a beverage) differ from each other in promoting weight loss and decreased fat mass (without energy restriction or dietary guidance) based on their chemical structure.

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Conditions studied

  • Body Weight

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Keywords

  • energy intake
  • energy expenditure
  • appetite
03

In context

Body Weight

1,223 studies on the registry are indexed under Body Weight; 131 are open to participants now.

This study's enrollment of 187 is above the median of 64 across 947 interventional studies indexed under Body Weight.

Browse Body Weight studies →

Lead sponsor

Purdue University is the lead sponsor of 168 studies on the registry; 23 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • BMI between 25-40 kg/M2
  • Non or rare users of LCS
  • Willing to consume large volumes of beverages daily

Exclusion criteria

Exclusion Criteria:

  • Weight change > 3kg in the last year
  • Plan to initiate a new diet plan in the next 6 months
  • Exhibit eating restraint
  • Pregnant/lactating
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
187 participants (actual)

Study arms

  • Active comparator
    Sucrose Sweetened Beverage

    100-140 g sucrose/day

    Dietary Supplement: Beverage

  • Experimental
    Aspartame Sweetened Beverage

    0.541-0.757 g aspartame Sweetened Beverage/day

    Dietary Supplement: Beverage

  • Experimental
    Saccharin Sweetened Beverage

    0.300-0.455 g saccharin Sweetened Beverage/day

    Dietary Supplement: Beverage

  • Experimental
    Sucralose Sweetened Beverage

    0.167-0.233 g sucralose Sweetened Beverage/day

    Dietary Supplement: Beverage

  • Experimental
    Rebaudioside A Sweeteened Beverage

    0.250-0.350 g rebaudioside A Sweetened Beverage/day

    Dietary Supplement: Beverage

Interventions

  • Dietary supplementBeverage

    Participants will receive 1.25 - 1.75 L of sweetened beverage a day for 12 weeks

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What researchers measure

Primary outcomes

  1. Body Weight

    Time frame: 12 weeks

  2. Body Composition

    Duel emission X-ray absorbtiometry

    Time frame: 12 weeks

  3. Energy Intake

    24 hr Dietary Recall

    Time frame: 12 weeks

  4. Appetite

    24 hr visual analog scale appetite

    Time frame: 12 weeks

  5. Energy Expenditure

    accelerometer

    Time frame: 12 weeks

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Study locations

1 site
  • Purdue University
    West Lafayette, Indiana 47907, United States
08

References and documents

Publications

  • Higgins KA, Mattes RD. A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. Am J Clin Nutr. 2019 May 1;109(5):1288-1301. doi: 10.1093/ajcn/nqy381. PubMed 30997499 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 21, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02928653
Lead sponsor
Purdue University
Responsible party
Richard Mattes (Distinguished Professor of Nutrition Sciences, Purdue University) — Principal investigator
First posted
Oct 10, 2016
Start date
Dec 2015
Primary completion
Feb 2018
Completion
Dec 2018
Last update
Mar 21, 2019

Study contacts

Richard D Mattes, PhD
principal investigator · Purdue University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2019. You cannot join it, but the record below documents what was studied.

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