An interventional study of Risperidone with Clozapine and Aripiprazole with Clozapine in Schizophrenia, sponsored by Shanghai Mental Health Center. Status unknown at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2019-03-13.
Sponsored by Shanghai Mental Health Center · Not applicable, Interventional, and Treatment
The Optimal Treatment for Treatment-resistant Schizophrenia
To explore the curative effect and safety of Risperidone，aripiprazole，sodium valproate，modified electroconvulsive therapy(MECT), or Magnetic seizure therapy(MST) with Clozapine in the treatment of treatment-resistant schizophrenia， and to provide the basis for clinical medication.
3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.
This study's planned enrollment of 150 is above the median of 70 across 2,872 interventional studies indexed under Schizophrenia.
Browse Schizophrenia studies →Shanghai Mental Health Center is the lead sponsor of 267 studies on the registry; 93 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
risperidone, dosage form: 1 mg, dosage and frequency:3.0\~6.0 mg/d; clozapine, dosage and frequency:300\~600 mg/d; duration: 8 weeks
Drug: Risperidone with Clozapine
aripiprazole, dosage form: 5 mg, dosage and frequency:15\~30 mg/day; clozapine, dosage and frequency:300\~600 mg/d; duration: 8 weeks
Drug: Aripiprazole with Clozapine
sodium valproate, dosage form: 250 mg, dosage and frequency:600\~1200 mg/day; clozapine, dosage and frequency:300\~600 mg/d; duration: 3 months.
Drug: sodium valproate with Clozapine
only clozapine, dosage and frequency:300\~600 mg/d;
Device: clozapine
10 times MECT for 4 weeks, if the PANSS reductive ratio is less 20% in the end of 8th week by the using of risperidone with clozapine, aripiprazole with clozapine, sodium valproate with clozapine, or clozapine.
Device: modified electroconvulsive therapy(MECT) with Clozapine
10 times MST for 4 weeks, if the PANSS reductive ratio is less 20% in the end of 8th week by the using of risperidone with clozapine, aripiprazole with clozapine, sodium valproate with clozapine, or clozapine.
Device: Magnetic seizure therapy(MST) with Clozapine
Risperidone may be used as a synergistic agent of clozapine in the treatment of treatment-resistant schizophrenia
Also known as: Risperidone Tablet
Aripiprazole may be used as a synergistic agent of clozapine in the treatment of treatment-resistant schizophrenia
Also known as: Aripiprazole Tablets
sodium valproate may be used as a synergistic agent of clozapine in the treatment of treatment-resistant schizophrenia
Also known as: Valproate
modified electroconvulsive therapy(MECT) may be used as a synergistic agent of clozapine in the treatment of treatment-resistant schizophrenia
Magnetic seizure therapy(MST) may be used as a synergistic agent of clozapine in the treatment of treatment-resistant schizophrenia
clozapine may be used in the treatment of treatment-resistant schizophrenia
Change from baseline in Positive and Negative Syndrome Scale [PANSS]
Time frame: At baseline, 4th week, 8th week,12th week
Change from baseline in clinical global impression [CGI]
Time frame: At baseline, 4th week, 8th week,12th week
Change from baseline in Simpson-Angus Scale [SAS]
Time frame: At baseline, 4th week, 8th week,12th week
Change from baseline in Abnormal Involuntary Movement Scale[AIMS]
Time frame: At baseline, 4th week, 8th week,12th week
Plan to share: No
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This study is status unknown, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.
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Shanghai Mental Health Center