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Status unknownNCT02923752WISPUpdated Aug 14, 2018

Whole Brain Vessel Wall Imaging in Stroke Patients (WISP): An International Multi-Center Registry

An observational study in Ischemic Stroke, sponsored by Cedars-Sinai Medical Center. Status unknown at 12 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-08-14.

Sponsored by Cedars-Sinai Medical Center · Observational

The sponsor has not verified this record recently (last verified Aug 2018), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
1,000
Ages
18 Years and older
Sex
All
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Study summary

This is a new vessel wall imaging-based stroke registry which will investigate the clinical utility of the whole-brain intracranial vessel wall Magnetic Resonance Imaging (MRI) technique in assessing the etiologies in patients with ischemic stroke.

Read the detailed description

The registry will focus on investigating the utility of whole-brain vessel wall MRI techniques in assessing the etiologies in patients with recent ischemic stroke. Patients who have had ischemic stroke (as confirmed by diffusion weighted MRI) and have had or will undergo 3D whole-brain vessel wall MRI within 8 weeks of symptom onset will be recruited into this study. It is anticipated that a total of 1000 subjects will be recruited from Feb 2017 to Feb 2019. Approximately 12 centers in the US and China will participate in the registry. MRI whole-brain vessel wall images will be analyzed for detection and characteristics of various vessel wall pathologies and association between vessel wall imaging findings and patient's clinical information.

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Conditions studied

  • Ischemic Stroke
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In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's planned enrollment of 1,000 is above the median of 160 across 1,692 observational studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Cedars-Sinai Medical Center is the lead sponsor of 441 studies on the registry; 108 are open to participants now.

Of its 62 completed or terminated interventional studies of FDA-regulated products, 47 (76%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients had recent ischemic stroke and have had or will undergo 3D whole-brain vessel wall MRI within 8 weeks of symptom onset.

Inclusion criteria

  • Male or female ≥ 18 years of age
  • Ischemic stroke onset within 8 weeks and confirmed by diffusion weighted MRI
  • Ability to read and understand informed consent

Exclusion criteria

Exclusion Criteria:

  • The cause of stroke has been confirmed to be related to cardiac or extracranial carotid or aorta pathologies.
  • Contraindications to MR imaging including mechanically, magnetically, or electrically activated implants, ferromagnetic implants and ferromagnetic foreign bodies, pregnancy.
  • Inability to tolerate MRI imaging secondary to an inability to lie supine or severe claustrophobia.
  • Non-compliant with visit instructions, including inability to lie still, hold breath or follow procedure instructions
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Study design

Observational model
Other
Time perspective
Prospective
Enrollment
1,000 participants (estimated)
Patient registry
No

Interventions

  • DeviceMRI

    Contrast-enhanced MRI

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What researchers measure

Primary outcomes

  1. Vessel wall pathology findings by MRI

    To identify vessel wall pathologies such as atherosclerosis, dissection, vasculitis

    Time frame: baseline

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Study locations

10 of 12 sites recruiting
  • Keck Hospital of the University of Southern California
    Los Angeles, California 90033, United States
    • May Anne Kim-Tenser, MD · Contact
    Not yet recruiting
  • Cedars-Sinai Medical Center
    Los Angeles, California 90048, United States
    • Shlee Song, MD · Contact
    Recruiting
  • Torrance Memorial Medical Center
    Torrance, California 90505, United States
    • Edward S. Nazareth, Stroke Coordinator · Contact
    Not yet recruiting
  • LiangXiang Hospital
    Beijiang, 100081, China
    • Huan Yu, MD · Contact
    Recruiting
  • Chaoyang Hospital, Capital Medical University
    Beijing, 100043, China
    • Tao Jiang, MD,PhD · Contact
    Recruiting
  • Beijing AeroSpace Center Hospital
    Beijing, 100049, China
    • Bin Cui, MD, PhD · Contact
    Recruiting
  • Xuanwu Hospital, Capital Medical University
    Beijing, 100053, China
    • Xunming Ji, MD., PhD · Contact
    Recruiting
  • West China Hospital, Sichuan University
    Chengdu, 610041, China
    • Jiayu Sun, MD, PhD · Contact
    Recruiting
  • Fujian Medical University Union Hospital
    Fuzhou, 350001, China
    • Bin Sun, MD, PhD · Contact
    Recruiting
  • Tianjin First Center Hospital
    Tianjin, 300192, China
    • Shuang Xia, MD, PhD · Contact
    Recruiting
  • Tianjin Huanhu Hospital
    Tianjin, 300350, China
    • Tong Han, MD, PhD · Contact
    Recruiting
  • The First Affiliated Hospital of Zhengzhou University
    ZhengZhou, 450052, China
    • Jingliang Cheng, MD, PhD · Contact
    Recruiting
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References and documents

Publications

  • Fan Z, Yang Q, Deng Z, Li Y, Bi X, Song S, Li D. Whole-brain intracranial vessel wall imaging at 3 Tesla using cerebrospinal fluid-attenuated T1-weighted 3D turbo spin echo. Magn Reson Med. 2017 Mar;77(3):1142-1150. doi: 10.1002/mrm.26201. Epub 2016 Feb 28. PubMed 26923198 ↗
  • Bodle JD, Feldmann E, Swartz RH, Rumboldt Z, Brown T, Turan TN. High-resolution magnetic resonance imaging: an emerging tool for evaluating intracranial arterial disease. Stroke. 2013 Jan;44(1):287-92. doi: 10.1161/STROKEAHA.112.664680. Epub 2012 Nov 29. No abstract available. PubMed 23204050 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 14, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02923752
Lead sponsor
Cedars-Sinai Medical Center
Responsible party
Zhaoyang Fan, PhD (Technical Director, 3T MRI, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center) — Principal investigator
First posted
Oct 5, 2016
Start date
Feb 1, 2017
Primary completion
Aug 1, 2019 (estimated)
Completion
Aug 1, 2019 (estimated)
Last update
Aug 14, 2018

Study contacts

Zhaoyang Fan, PhD
Contact
zhaoyang.fan@cshs.org
310 248-8661
Qi Yang, MD, PhD
Contact
qi.yang@cshs.org
310 248-8676
Zhaoyang Fan, PhD
principal investigator · Cedars-Sinai Medical Center
Qi Yang, MD,PhD
principal investigator · Cedars-Sinai Medical Center
Debiao Li, PhD
principal investigator · Cedars-Sinai Medical Center

Oversight

Data monitoring committee
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.

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