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CompletedNCT02910856ELDERL-IEUpdated Jan 8, 2024

Infective Endocarditis in the Elderly

An observational study in Infective Endocarditis, sponsored by Central Hospital, Nancy, France. Completed at 1 site in France. Open to participants aged 75 Years and older. Per ClinicalTrials.gov, last updated 2024-01-08.

Sponsored by Central Hospital, Nancy, France · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
120
Ages
75 Years and older
Sex
All
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Study summary

ELDERL-IE is a multicenter national prospective observational study.

The main objective is to describe geriatric characteristics (comorbidities, cognitive status, autonomy, nutritional status, balance and walking) in patients aged 75 years or older with infective endocarditis (IE).

The secondary objectives are to assess the impact of geriatric features on the medico - surgical care and on morbidity and mortality at 3 months after the end of the hospitalization, and to describe the initial clinical presentation and diagnostic modalities in the IE elderly.

Read the detailed description

Population monitoring:

Clinical, therapeutic, biological, microbiological, echocardiographic and geriatric data are collected. (M-2/3 before inclusion; D-15 before inclusion; D0; M3; vital status at 1 year)

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Conditions studied

  • Infective Endocarditis

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In context

Endocarditis

173 studies on the registry are indexed under Endocarditis; 57 are open to participants now.

This study's enrollment of 120 is below the median of 225 across 82 observational studies indexed under Endocarditis.

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Lead sponsor

Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
75 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients older than 75 years are eligible if they are considered and treated as a case of IE by physicians ensuring their medical care.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • all patients older than 75 years are eligible if they are considered and treated as a case of IE by physicians ensuring their medical care.
  • the patient should be treated in one of the clinical sites participating at the study.
  • the patient should benefit during initial hospitalization of a geriatric assessment, in addition to the usual clinical and therapeutic management of such patients.

Exclusion criteria

Exclusion criteria :

  • patients not fulfilling the criteria of definite or possible endocarditis according to Duke modified by Li diagnostic classification that will be applied after collection of all the data at the discharge of the patient.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
120 participants (actual)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Change from baseline geriatric characteristics at 3 months

    OMS score

    Time frame: 3 months after inclusion

Secondary outcomes

  1. Three months mortality

    Mortality rate at 3 months

    Time frame: 3 months after inclusion

  2. One year mortality

    Mortality rate at 1 year

    Time frame: 1 year after inclusion

  3. Change from baseline geriatric characteristics at 3 months

    Karnofsky'score

    Time frame: 3 months after inclusion

  4. Change from baseline geriatric characteristics at 3 months

    Score MNA

    Time frame: 3 months after inclusion

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Study locations

1 site
  • Central Hospital - University Hospital
    Nancy, 54000, France
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References and documents

Publications

  • Forestier E, Fraisse T, Roubaud-Baudron C, Selton-Suty C, Pagani L. Managing infective endocarditis in the elderly: new issues for an old disease. Clin Interv Aging. 2016 Sep 2;11:1199-206. doi: 10.2147/CIA.S101902. eCollection 2016. PubMed 27621607 ↗
  • Forestier E, Roubaud-Baudron C, Fraisse T, Patry C, Gavazzi G, Hoen B, Carauz-Paz P, Moheb-Khosravi B, Delahaye F, Sost G, Paccalin M, Nazeyrollas P, Strady C, Alla F, Selton-Suty C; AEPEI and the GInGer Elderl-IE study group; AEPEI and the GInGer Elderl-IE study group. Comprehensive geriatric assessment in older patients suffering from infective endocarditis. A prospective multicentric cohort study. Clin Microbiol Infect. 2019 Oct;25(10):1246-1252. doi: 10.1016/j.cmi.2019.04.021. Epub 2019 May 2. PubMed 31055167 ↗
  • Forestier E, Selton-Suty C, Roubaud-Baudron C. Managing infective endocarditis in older patients: do we need a geriatrician? Aging Clin Exp Res. 2021 Mar;33(3):719-722. doi: 10.1007/s40520-019-01400-6. Epub 2019 Nov 22. PubMed 31758501 ↗
  • N'cho-Mottoh MB, Erpelding ML, Roubaud C, Delahaye F, Fraisse T, Dijos M, Ennezat PV, Fluttaz A, Richard B, Beaufort C, Nazeyrollas P, Brasselet C, Pineau O, Tattevin P, Curlier E, Iung B, Forestier E, Selton-Suty C. The impact of transoesophageal echocardiography in elderly patients with infective endocarditis. Arch Cardiovasc Dis. 2023 May;116(5):258-264. doi: 10.1016/j.acvd.2023.04.001. Epub 2023 Apr 25. PubMed 37147149 ↗

Individual participant data

Plan to share: Undecided

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 8, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02910856
Collaborators
Fondation Cœur et Recherche
Responsible party
Christine Selton-Suty (Doctor, Central Hospital, Nancy, France) — Principal investigator
First posted
Sep 22, 2016
Start date
Mar 2015
Primary completion
Jun 2016
Completion
Jul 2017
Last update
Jan 8, 2024

Study contacts

Christine Selton-Suty, MD
principal investigator · Central Hospital, Nancy, France

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2024. You cannot join it, but the record below documents what was studied.

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