An interventional study of fMRI and tractography in Oligoastrocytoma, Astrocytoma and Oligodendroglioma, sponsored by University Hospital, Montpellier. Completed. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2020-09-02.
Sponsored by University Hospital, Montpellier · Not applicable, Interventional, and Other
According to the O.M.S. Classification, grade 2 glioma is a pre-cancerous lesion, slowly progressive, infiltrating the central nervous system, mainly affecting young adults.
This surgery should nevertheless be conducted in awake condition to achieve two conflicting goals: get maximum brain tissue infiltrated by the tumor while preserving the integrity of functional structures. So awake after opening the skull, the patient undergoes a series of preoperative tests, administered by a speech therapist present in the operating room. This procedure allows the neurosurgeon to establish an individual functional brain mapping in real time, through the observation by the SLP of the patient's answers to direct electrical stimulation applied to the cortical and sub-cortical. This support is based on the extraordinary plasticity demonstrated by the brain in the presence of a slowly progressive lesion. To ensure the patient the highest achievable load should increase our understanding of brain function, including the neural bases of language, glioma grade 2 is predominantly localized functional area of language.
According to the O.M.S. Classification, grade 2 glioma is a pre-cancerous lesion, slowly progressive, infiltrating the central nervous system, mainly affecting young adults. Surgical excision of the tumor is the most appropriate care, with or without chemotherapy or radiotherapy.
This surgery should nevertheless be conducted in awake condition to achieve two conflicting goals: get maximum brain tissue infiltrated by the tumor while preserving the integrity of functional structures. So awake after opening the skull, the patient undergoes a series of preoperative tests (motor, sensory and / or language), administered by a speech therapist present in the operating room. This procedure allows the neurosurgeon to establish an individual functional brain mapping in real time, through the observation by the SLP of the patient's answers to direct electrical stimulation applied to the cortical and sub-cortical. This support is based on the extraordinary plasticity demonstrated by the brain in the presence of a slowly progressive lesion. To ensure the patient the highest achievable load should increase our understanding of brain function, including the neural bases of language, glioma grade 2 is predominantly localized functional area of language. Many studies apply to highlight the cortical organization of language, but the study of subcortical beams involved in this function, especially in the semantic language processing, has so far received less attention .
The use of electric direct intraoperative stimulation helps highlight the cortico-subcortical networks involved in language processing.
The new imaging techniques allow us to better understand the functional brain anatomy: the Diffusion Tensor can view the white matter bundles based on the diffusion of water molecules, functional MRI to visualize areas cortical functional.
420 studies on the registry are indexed under Astrocytoma; 76 are open to participants now.
This study's enrollment of 63 is above the median of 30 across 346 interventional studies indexed under Astrocytoma.
Browse Astrocytoma studies →University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients carry a grade glioma 2 functional area of language and presenting the information to receive surgical care provided in awake for the first time.
or Healthy volunteers will be selected using a matching age and sex of patients in the study (matched to a patient on two of the first forty patients).
Exclusion Criteria:
Patient with grade 2 glioma use a neuropsychological examination and brain imaging (fMRI and tractography)
Device: fMRI · Procedure: tractography · Other: neuropsychological examination
healthy volunteers use a neuropsychological examination and brain imaging (fMRI and tractography)
Device: fMRI · Procedure: tractography · Other: neuropsychological examination
Patient with grade 2 glioma and healthy volunteers use a brain imaging (fMRI)
Patient with grade 2 glioma and healthy volunteers use a brain imaging (tractography)
Patient with grade 2 glioma and healthy volunteers use a neuropsychological examination
functional score
The intraoperative testing is performed by an evaluator (speech / neuropsychologist), present in the operating room, the patient's side. Its role is to identify functional disturbances induced by direct electrical stimulation. To do this, two standardized tests are administered to the patient alternately for the duration of the awake period. These tests are presented on a computer screen in PowerPoint format, with a picture every four seconds.
Time frame: 1 day
Evaluation orthophonic
* Spontaneous Speech * Test oral denomination: DO. 80 with computerized measurement of reaction time * Verbal Fluence * Categorical: animals * Formal: letter / p / * Test semantic matching: PPTT with computerized measurement of the reaction time * trial test semantics / phonology * Image Designation
Time frame: 1 day
Evaluation orthophonic
* Spontaneous Speech * Test oral denomination: DO. 80 with computerized measurement of reaction time * Verbal Fluence * Categorical: animals * Formal: letter / p / * Test semantic matching: PPTT with computerized measurement of the reaction time * trial test semantics / phonology * Image Designation
Time frame: 5 day
Evaluation orthophonic
* Spontaneous Speech * Test oral denomination: DO. 80 with computerized measurement of reaction time * Verbal Fluence * Categorical: animals * Formal: letter / p / * Test semantic matching: PPTT with computerized measurement of the reaction time * trial test semantics / phonology * Image Designation
Time frame: 3 month
Imagery Data
Imagery Data
Time frame: 1 day
Imagery Data
Imagery Data
Time frame: 5 day
Imagery Data
Imagery Data
Time frame: 6 month
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in May 2011. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University Hospital, Montpellier