A Phase 4 interventional study of Bone grafting in Alveolar Ridge Trauma and Bone Resorption, sponsored by Institute Franci. Completed at 1 site in Italy. Open to participants aged 25 Years and older. Per ClinicalTrials.gov, last updated 2025-11-19.
Sponsored by Institute Franci · Phase 4, Interventional, and Treatment
An open, prospective, randomized, multicenter study focused on the ridge diminution in case of grafting of fresh extraction sockets with Bio-Oss Collagen, Bio-Gide (Geistlich Pharma, Wolhusen, Switzerland), placing Dentsply implants (Astra Tech System).
The removal of at least 2 adjacent teeth would cause more advanced hard tissue loss during healing than that occurring after removal of a single tooth with adjacent teeth present. In order to maintain the dimension of the ridge following tooth removal, bone grafts and bone substitutes have also been placed in the extraction socket. So far no data have been reported on the effect of removal of multiple adjacent teeth on bone loss at various aspects of the edentulous sites. Furthermore, the potential effect on ridge contraction of implant placement in multiple fresh extraction sites is not documented. Therefore, the objective of the study is to evaluate the possibility of counteracting un favourable ridge modeling after multiple tooth extractions by placing mineral bovine bone in the extraction sockets and covering the wound with a native collagen membrane. In addition, the possibility of placing implants in the grafted sites is evaluated after six month of healing. For these purpose 40 subjects with 2 or more fresh adjacent extraction sites in need of two or more implants replacing teeth will be enrolled. Ridge dimensional changes will be measured after 6 months of healing; marginal bone loss will be measured after 3-years follow-up from the baseline (prosthetic delivery).
167 studies on the registry are indexed under Bone Resorption; 28 are open to participants now.
This study's enrollment of 40 is above the median of 24 across 146 interventional studies indexed under Bone Resorption.
Browse Bone Resorption studies →Institute Franci is the lead sponsor of 4 studies on the registry; none are open to participants now.
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Inclusion Criteria:intact extraction sockets following removal of the natural teeth defined by:
Exclusion Criteria:
The possibility of counteracting unfavourable ridge modelling after multiple tooth extractions by placing bone grafting material in the fresh extraction sites.
Device: Bone grafting
ridge modelling after multiple tooth extractions.
Device: Bone grafting
Cone Beam Computerized Tomographic (CBCT) examination at the center of each extraction socket, between the sockets, at the septum next to adjacent teeth.
Measurements of alveolar ridge dimensional changes in the first 6 months of healing
Time frame: Up to 24 weeks
Standard intraoral radiograph of each experimental socket and inter-dental bone
Changes in crestal bone level between baseline (prosthetic restoration) and follow-up (3 years later)
Time frame: 3 years follow up
Plan to share: Undecided
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This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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