CompletedNCT02890680Updated Apr 12, 2017

Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery

An interventional study of Platelet-rich fibrin and Control group in Fibrin/Therapeutic Use, Blood Platelets and Molar, Third, sponsored by Rio de Janeiro State University. Completed at 1 site in Brazil. Open to participants aged 16 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-04-12.

Sponsored by Rio de Janeiro State University · Not applicable, Interventional, and Treatment

Phase: Not applicable
Study type: Interventional
Enrollment: 20
Allocation: Randomized
Ages: 16 Years to 29 Years
Sex: All

Study summary

The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.

Conditions studied

Fibrin/Therapeutic Use
Blood Platelets
Molar, Third
Bone Regeneration

Browse trials for

Tooth, Impacted 195

Keywords

platelet-rich fibrin
third molar
bone regeneration

In context

Tooth, Impacted

195 studies on the registry are indexed under Tooth, Impacted; 20 are open to participants now.

This study's enrollment of 20 is below the median of 53 across 164 interventional studies indexed under Tooth, Impacted.

Browse Tooth, Impacted studies →

Lead sponsor

Rio de Janeiro State University is the lead sponsor of 62 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 16 Years to 29 Years
Sexes eligible: All
Accepts healthy volunteers: Yes

Inclusion criteria

Healthy patients
Preoperative platelet count higher than 150,00/ mm3
Patient who required bilateral mandibular third molar extractions

Exclusion criteria

Exclusion Criteria:

Smokers patients
Alcoholics patients
Patients whom the inferior second molar was missing
Patients who had acute pericoronitis on the inferior third molar
Severe periodontal disease

Study design

Phase: Not applicable
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Triple (Participant, Investigator, Outcomes assessor)
Enrollment: 20 participants (actual)

Study arms

Experimental
Platelet-rich fibrin group
Use platelet-rich fibrin after mandibular third molar extraction
Procedure: Platelet-rich fibrin
Placebo comparator
Control group
mandibular third molar extraction
Procedure: Control group

Interventions

ProcedurePlatelet-rich fibrin
ProcedureControl group

What researchers measure

Primary outcomes

Change in bone density through tomography evaluation
Time frame: Change from Baseline bone measurement at three months after surgery

Secondary outcomes

Change in periodontal-probing depth measurement on distal aspect of the second molar through Clinical evaluation
Time frame: Change from baseline at 3 months after surgery
Pain through Visual Analogue Scale
Time frame: 1st day after surgery
Pain through Visual Analogue Scale
Time frame: 3rd day after surgery
Pain through Visual Analogue Scale
Time frame: 7th day after surgery
Soft tissue healing through Clinical evaluation numeric scale
Time frame: 7th day after surgery

Study locations

1 site

João Canellas
Rio de Janeiro, 24240170, Brazil

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Apr 12, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT02890680
Lead sponsor: Rio de Janeiro State University
Responsible party: João Vitor dos Santos Canellas, DDS MS (MSc, Rio de Janeiro State University) — Principal investigator
First posted: Sep 7, 2016
Start date: Aug 2016
Primary completion: Nov 2016
Completion: Jan 2017
Last update: Apr 12, 2017

Study contacts

João Vitor Canellas, DDS; MSc

principal investigator · Rio de Janeiro University State

Oversight

Data monitoring committee: Yes

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2017. You cannot join it, but the record below documents what was studied.

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