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CompletedNCT02854475Updated Aug 3, 2016

Confocal Raman Spectroscopy: in Vivo Measurement of Physiological Skin Parameters

An interventional study of Venous blood collection and Raman spectroscopy in Dermatologic Disorders and Disorder of Cholesterol Metabolism, sponsored by University of Vienna. Completed. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-08-03.

Sponsored by University of Vienna · Not applicable and Interventional

Phase
Not applicable
Study type
Interventional
Enrollment
15
Allocation
Not applicable
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The purpose of this study is to

I. determine several skin parameters, for example natural moisturizing factor (NMF) and cholesterol, with Raman spectroscopy in vivo and

II. compare the results with the corresponding cholesterol levels measured in venous blood.

Read the detailed description

In vivo Raman experiments will be carried out weekly on voluntary participants using a RiverDiagnostics gen2-SCA Skin Composition Analyzer (RiverDiagnostics, Rotterdam, Netherlands). All experiments will be carried out on the volar forearm. Semi-quantitative concentration profiles for several skin parameters will be determined, for example natural moisturizing factor (NMF) and cholesterol.

Additionally the total cholesterol level will be detected by venous blood sample analysis. The blood samples will be taken weekly within two weeks, similar to the Raman measurements.

02

Conditions studied

  • Dermatologic Disorders
  • Disorder of Cholesterol Metabolism

Browse trials for

Keywords

  • skin parameters
  • cholesterol
  • Raman spectroscopy
03

In context

Skin Diseases

538 studies on the registry are indexed under Skin Diseases; 92 are open to participants now.

This study's enrollment of 15 is below the median of 60 across 372 interventional studies indexed under Skin Diseases.

Browse Skin Diseases studies →

Lead sponsor

University of Vienna is the lead sponsor of 47 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Provision of subject informed consent
  • Female or male aged between 18 and 65 years

Exclusion criteria

Exclusion Criteria:

  • Pregnancy
  • Chronic skin conditions
05

Study design

Phase
Not applicable
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
15 participants (actual)

Study arms

  • Experimental
    Proband group

    Raman spectroscopy and venous blood collection

    Procedure: Venous blood collection · Procedure: Raman spectroscopy

Interventions

  • ProcedureVenous blood collection

    weekly within two weeks

  • ProcedureRaman spectroscopy

    weekly within two weeks, on the volar forearm, using a RiverDiagnostics gen2-SCA Skin Composition Analyzer

06

What researchers measure

Primary outcomes

  1. Correlation of the fasting total cholesterol levels measured in skin with confocal Raman spectroscopy and in venous blood collected by venipuncture

    Time frame: 2 weeks

Secondary outcomes

  1. Concentration curves of various skin substances, such as NMF, urea and water as evidence for the eligibility of confocal Raman spectroscopy for the in vivo measurement of skin

    Time frame: 2 weeks

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 3, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02854475
Lead sponsor
University of Vienna
Collaborators
Medical University of Vienna
Responsible party
Lisa Binder (Mag. pharm., University of Vienna) — Principal investigator
First posted
Aug 3, 2016
Start date
Jul 2016
Primary completion
Jul 2016
Completion
Jul 2016
Last update
Aug 3, 2016

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.

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