A Phase 4 interventional study of Dexmedetomidine and Normal saline in Restrictive Lung Disease, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2017-08-29.
Sponsored by Cairo University · Phase 4, Interventional, and Treatment
The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients
The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively
3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.
This study's enrollment of 42 is below the median of 72 across 2,118 interventional studies indexed under Lung Diseases.
Browse Lung Diseases studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
Patients will receive either, Dexmedetomidine (Precedex, Hospira, Lake forest, IL, USA) in a dose of (1ug/Kg LBW) bolus followed by 0.5ug/Kg continuous infusion for one hour
Drug: Dexmedetomidine
Patients will receive normal saline
Drug: Normal saline
Dexmedetomidine infusion was previously reported to improve oxygenation and lung dynamics in patients with obstructive lung diseases. In our study we are going to investigate its effect on oxygenation and lung dynamics in restrictive lung disease
Also known as: Precedex
Normal saline
Also known as: Saline
Oxygenation
assessed by P/F ratio
Time frame: 2 hours
Lung mechanics
lung compliance and dead space
Time frame: 2 hours
arterial blood pressure
arterial blood pressure measured in mmHg
Time frame: 2 hours
plateau airway pressure
plateau airway pressure measured in cmH2o
Time frame: 2 hours
heart rate
number of heart beats per minute
Time frame: 2 hours
Plan to share: No
This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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Cairo University