An observational study in Oral Lichen Planus, sponsored by Cairo University. Completed. Open to participants aged 45 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-07-15.
Sponsored by Cairo University · Observational
60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain reaction and immunohistochemistry.
60 individuals were subdivided into 3 groups, into 2 groups, 30 patients with oral lichen planus, 30 control individuals having age, gender and periodontal status matched with both patients groups acting as a control group. Relative gene expression of miRNA-138 was estimated using Quantitative real-time polymerase chain reaction technique in oral mucosa of both oral lichen planus patients and control subjects. Sub grouping of oral lichen planus patients were performed into reticular, atrophic and erosive groups (n=10 each). Cyclin D1 gene expression was estimated using Quantitative real-time polymerase chain reaction technique and Cyclin D1 protein level was estimated using immunohistochemistry.
139 studies on the registry are indexed under Lichen Planus, Oral; 24 are open to participants now.
This study's enrollment of 60 is below the median of 78 across 35 observational studies indexed under Lichen Planus, Oral.
Browse Lichen Planus, Oral studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
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60 individuals were subdivided into 2 groups, 30 patients suffering from oral lichen planus and 30 individuals having age, gender and periodontal status matched with both patients groups acting as a control group.
Exclusion Criteria:
30 patients suffering from reticular, erosive and atrophic oral lichen planus
30 individuals age, gender and periodontal status matched with oral lichen planus patients and not suffering from any oral mucosal lesions or periodontal disease.
expression of miRNA-138
expression of miRNA-138 in oral mucosa of patients with oral lichen planus
Time frame: 1 day
gene expression of cyclin D1
gene expression of cyclin D1 in oral mucosa of patients with oral lichen planus
Time frame: 1 day
protein expression of cyclin D1
protein expression of cyclin D1 in oral mucosa of patients with oral lichen planus
Time frame: 1 day
No study locations are listed for this record.
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Cairo University