An interventional study of IRMf and Mini International Neuropsychiatric Interview in Bipolar Disorder, Schizophrenia, sponsored by CHU de Reims. Status unknown at 1 site in France. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-07-15.
Sponsored by CHU de Reims · Not applicable and Interventional
Theory of mind (TOM), a main component of social cognition processes, refers to the capacity to infer one's own and other person's mental states. Deficits in social cognition are found in patients with schizophrenia and bipolar disorder. The purpose of this study is to compare the neurofunctional profiles of schizophrenic patients, bipolar patients and healthy participants during the performance of a TOM task. Results may help to understand the neural bases of the impairments in social cognition in schizophrenia and bipolar disorder, which may in turn help to propose potential new psychosocial therapeutic approaches in these disorders.
Theory of mind (TOM) refer to the cognitive ability to attribute mental states to others, which plays an essential role in social communications and interactions between individuals. In several recent papers, it was shown that TOM is impaired in schizophrenia and bipolar disorder. This impairment strongly affects the quality of life in patients suffering from these disorders. The investigators study aims to explore the neural correlates of TOM in schizophrenic and bipolar patients, in comparison with those of healthy participants. These studies will be conducted on 30 schizophrenic patients, 30 bipolar patients, and 60 healthy participants, matched on age and educational level to each patient group. The investigators expect that the study of combined behavioral (neuropsychological tests) and neuro-anatomical data will allow to understand the pathophysiology of the alteration of social cognition processes in these illnesses.
3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.
This study's planned enrollment of 120 is above the median of 70 across 2,872 interventional studies indexed under Schizophrenia.
Browse Schizophrenia studies →CHU de Reims is the lead sponsor of 267 studies on the registry; 50 are open to participants now.
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Behavioral: IRMf · Behavioral: Mini International Neuropsychiatric Interview · Behavioral: Positive And Negative Syndrom Scale · Behavioral: Young Mania Rating Scale · Behavioral: Hamilton Depression Scale
Behavioral: IRMf · Behavioral: Mini International Neuropsychiatric Interview · Behavioral: Positive And Negative Syndrom Scale · Behavioral: Young Mania Rating Scale · Behavioral: Hamilton Depression Scale
Neuropsychological test : Mini International Neuropsychiatric Interview (M.I.N.I.)
Time frame: Up to 15 days after inclusion
Young Mania Rating Scale
Time frame: Up to 15 days after inclusion
Hamilton Depression Scale
Time frame: Up to 15 days after inclusion
Scale for the Assessment for Thought, Language and Communication
Time frame: Up to 15 days after inclusion
This study is status unknown, as verified in Jun 2016. You cannot join it, but the record below documents what was studied.
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