An interventional study of Isomaltulose and Glucose in Hunger, sponsored by Swansea University. Completed at 1 site in United Kingdom. Open to female participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-07-11.
Sponsored by Swansea University · Not applicable, Interventional, and Treatment
Reducing the glycaemic load (GL) of the diet may benefit appetite control but its utility is complicated by psychological influences on eating. Disinhibited behaviour, a risk factor for overconsumption, is characterized by reduced prefrontal cortex activity, which in turn directly modulates vagal tone; a phenomenon inversely associated with blood glucose (BG) and insulin levels. This double blind randomised controlled trial explores the influence of disinhibited eating and vagal tone (heart rate variability) on the postprandial response to GL and hunger.
There is growing recognition that lowering the glycaemic load of the diet might reduce a range of cardiovascular risk factors such as raised plasma triglycerides, HbA1c and C reactive protein and aid in body weight regulation. A proposed mechanism includes higher satiety and prolonged satiation by virtue of improved postprandial metabolic control, although, whether lower GL meals result in greater weight loss or increased satiety is still a matter of debate. One matter complicating the issue is that the desire to consume food may be driven by psychological factors; food reward centres in the brain may override hormonal regulation of food intake. Amongst psychological factors disinhibition has the largest and most consistent body of empirical data that associates it with weight gain although the mechanisms involved are unknown. This study will investigate whether, irrespective of BMI or habitual diet, disinhibited eaters have greater glycaemic excursions following a high glycaemic load drink and whether this predicts subsequent satiation.
Swansea University is the lead sponsor of 40 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants were excluded if they
75g of glucose dissolved in 500ml provided in a clear plastic tumbler.
Dietary Supplement: Glucose
75g of isomaltulose dissolved in 500ml provided in a clear plastic tumbler.
Dietary Supplement: Isomaltulose
500ml water sweetened with sucralose provided in a clear plastic tumbler.
Dietary Supplement: Sweetened water
75g Isomaltulose (low glycaemic load intervention)
75g Glucose (high glycaemic load intervention)
Sweetened water will be used as a control
Change in blood glucose
Blood glucose was monitored from finger pricks using an ExacTech sensor (Medisense Britain Limited) that using an enzymic method, coupled with microelectronic measurement. Change in blood glucose from baseline to after 30 minutes will assess the speed of incline.
Time frame: From baseline to 30 minutes
Change in blood glucose
As above to assess the speed of decline.
Time frame: from 30 to 150minutes
Hunger
Participants were asked to respond to the question "how hungry are you feeling right now" on a single 100mm visual analogue scale anchored by "Not at all" and "Extremely".
Time frame: 30, 150 minutes
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Swansea University