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CompletedNCT02826915AEHCEEUpdated Jun 12, 2026

Electro- Hemodynamic Activity in Children: Combined Analysis by Video -EEG Spectroscopy and Near-infrared (NIRS )

An observational study in Epilepsy, sponsored by Centre Hospitalier Universitaire, Amiens. Completed at 1 site in France. Open to participants aged 0 Years to 16 Years. Per ClinicalTrials.gov, last updated 2026-06-12.

Sponsored by Centre Hospitalier Universitaire, Amiens · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
37
Ages
0 Years to 16 Years
Sex
All
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Study summary

Epilepsy in children is a major public health issue. It is the first neurological disease of the child.

Read the detailed description

Epilepsy in children is a major public health issue. It is the first neurological disease of the child. The specific incidence of epilepsy rates were highest during the first year of life, between 75,105 and 250,105 hab.an hab. year and remain high in the age group between 0 and 10 years. Epilepsies predictions are varied. They can be spontaneously benign, drug-, chemically dependent or drug-resistant. These, refractory epilepsies, represent 20% of epilepsy as a child and adolescent than adult is about 1200 children and 1200 adults Picardy. The validation of non-invasive investigative tools is becoming a necessity in the management of drug-resistant epilepsies especially when a surgical decision is envisaged. The aftermath (motor, cognitive, sensory) appear to rule early; but they are sometimes limited to learning deficits detected later in the school curriculum. The investigators know that defects in neuronal electrical activity (eg critical discharges) induce a metabolic response and conversely metabolic disturbances can cause abnormal electrical activity. It is therefore important to have tools to better characterize the interactions between these two mechanisms to better understand brain function in the brain during development and during pathological situations. The investigators lack quantitative criteria regarding the impact of crises on the metabolic activity and thus predictive criteria consequences of crises on brain function. The deleterious hazard must be considered at all ages in both structures to causing seizures than in those where the crisis spread. The functional characterization, electrical, metabolic and anatomic pathology of these networks is necessary and contributes to a better understanding of physiological and pathological brain function, and helps to define the most appropriate treatment strategy.

About childhood epilepsy, analysis of the EEG allows in 75% of cases to find predictive patterns characteristic of becoming. However in 25% of cases, we lack predictive objective criteria. This highlights the importance of developing analysis tools for more accurate and efficient brain function and to improve the management and evaluation of the prognosis of these children.

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Conditions studied

  • Epilepsy

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Keywords

  • newborn
  • infant
  • child
  • EEG
  • NIRS
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In context

Epilepsy

1,805 studies on the registry are indexed under Epilepsy; 417 are open to participants now.

This study's enrollment of 37 is below the median of 102 across 521 observational studies indexed under Epilepsy.

Browse Epilepsy studies →

Lead sponsor

Centre Hospitalier Universitaire, Amiens is the lead sponsor of 576 studies on the registry; 178 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
0 Years to 16 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The inclusion of patients in the study will be conducted by doctors of the unit of pediatric neurology, intensive care or critical care of the Amiens hospital. The purchases will be made as part of the normal management of all children who have a électroecéphalographique followed.

Inclusion criteria

- Any child 0-16 years with partial epilepsy and / or interictal spikes located on the standard EEG recordings.

Exclusion criteria

Exclusion Criteria:

  • All children with severe congenital malformation
  • Any refusal of a parent
  • Any child with generalized epilepsy or diffuse interictal spikes
  • Any child with a serious deterioration in the general condition and vital functions
  • Any child with dermatitis of the face or scalp
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
37 participants (actual)
Patient registry
No

Interventions

  • DeviceNear Infra Red Spectroscopy (NIRS)
  • DeviceElectroencephalogram (EEG)
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What researchers measure

Primary outcomes

  1. HbO

    concentration modification (Hz) of oxygenated hemoglobin (HbO) during the interictal spikes and seizures in infants and children.

    Time frame: Hour 1

  2. HHb

    concentration modification (Hz) of deoxygenated hemoglobin (HHb) during the interictal spikes and seizures in infants and children.

    Time frame: Hour 1

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Study locations

1 site
  • CHU Amiens
    Amiens, 80054, France
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 12, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02826915
Lead sponsor
Centre Hospitalier Universitaire, Amiens
Responsible party
Sponsor
First posted
Jul 11, 2016
Start date
Feb 5, 2010
Primary completion
Mar 21, 2019
Completion
Mar 21, 2019
Last update
Jun 12, 2026

Study contacts

Fabrice WALLOIS, MD, PhD
principal investigator · CHU Amiens
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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