CClinicalTrials.gg
Status unknownNCT02814162Updated Mar 31, 2017

Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.

An observational study in Subarachnoid Hemorrhage, Aneurysmal, sponsored by Tang-Du Hospital. Status unknown at 1 site in China. Open to participants aged 16 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-03-31.

Sponsored by Tang-Du Hospital · Observational

The sponsor has not verified this record recently (last verified Mar 2017), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
100
Ages
16 Years to 90 Years
Sex
All
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Study summary

The purpose of this study is to evaluate the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage patients.

Read the detailed description

Adiponectin (APN) is an abundant protein hormone derived from adipose tissue. It has been suggested to exert anti-inflammatory, antiatherogenic, and vascular protective. Subarachnoid hemorrhage (SAH) comprises about 5% of all strokes with high mortality and permanent disability rates. Although many patients survive from the initial hemorrhage or rebleeding, they suffered from long-term delayed neurological deficits (DNDs), including stroke, delayed cerebral ischemia, cognitive and neuropsychological abnormalities that seriously impact overall function and quality of life. Ruptured cerebral aneurysms are the most common cause of SAH. There is growing evidence supporting APN act as a predictive factor for SAH. The observational study will focus on the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage (aSAH).

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Conditions studied

  • Subarachnoid Hemorrhage, Aneurysmal

Keywords

  • Subarachnoid Hemorrhage, Aneurysmal
  • Predictive
  • Adiponectin
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In context

Subarachnoid Hemorrhage

509 studies on the registry are indexed under Subarachnoid Hemorrhage; 124 are open to participants now.

This study's planned enrollment of 100 is below the median of 117 across 226 observational studies indexed under Subarachnoid Hemorrhage.

Browse Subarachnoid Hemorrhage studies →

Lead sponsor

Tang-Du Hospital is the lead sponsor of 164 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
16 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients with aneurysmal subarachnoid hemorrhage who are hospitalized within 24 hours from onset.

Inclusion criteria

  • Age>18yrs and age\<90yrs
  • It shows subarachnoid hemorrhage (SAH) based on computed tomography (CT) scan on admission
  • Aneurysmal subarachnoid hemorrhage confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography (DSA)
  • SAH grade is assessed by Hunt \& Hess classification
  • Informed consented

Exclusion criteria

Exclusion Criteria:

  • Traumatic subarachnoid hemorrhage
  • Patients with cerebral herniation or highly possible to occur within 2 days from SAH
  • Length of hospital stay is expected to be less than 5 days
  • Duration from onset to admission is more than 48 hours
  • Disturbance of communication or poor compliance to blood collection, imaging examination and follow-up
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No
Biospecimen retention
Samples without dna
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What researchers measure

Primary outcomes

  1. Incidence of cerebral vasospasm and delayed cerebral ischemia

    Proved by clinical and radiologic evidence

    Time frame: 30 days post SAH

Secondary outcomes

  1. Death

    Time frame: 30 days post SAH

  2. National institutes of health stroke scale (NIHSS) score

    Assessing by senior neurosurgeons

    Time frame: On discharge or 14 days (whichever occurs first) and 30 days post SAH

  3. Modified Rankin scale (mRS)

    By phone call following-up

    Time frame: 30 days and 90days post SAH

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Study locations

1 of 1 sites recruiting
  • Tandu Hospital, Fourth Military Medical University
    Xi'an, Shaanxi 710038, China
    Recruiting
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References and documents

Publications

  • Thundyil J, Tang SC, Okun E, Shah K, Karamyan VT, Li YI, Woodruff TM, Taylor SM, Jo DG, Mattson MP, Arumugam TV. Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Exp Transl Stroke Med. 2010 Aug 11;2(1):15. doi: 10.1186/2040-7378-2-15. PubMed 20701790 ↗
  • Osuka K, Watanabe Y, Yasuda M, Takayasu M. Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage. Neurosci Lett. 2012 Apr 11;514(1):2-5. doi: 10.1016/j.neulet.2011.12.041. Epub 2012 Jan 3. PubMed 22230897 ↗
  • Psilopanagioti A, Papadaki H, Kranioti EF, Alexandrides TK, Varakis JN. Expression of adiponectin and adiponectin receptors in human pituitary gland and brain. Neuroendocrinology. 2009;89(1):38-47. doi: 10.1159/000151396. Epub 2008 Aug 13. PubMed 18698133 ↗
  • Kos K, Harte AL, da Silva NF, Tonchev A, Chaldakov G, James S, Snead DR, Hoggart B, O'Hare JP, McTernan PG, Kumar S. Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus. J Clin Endocrinol Metab. 2007 Mar;92(3):1129-36. doi: 10.1210/jc.2006-1841. Epub 2007 Jan 9. PubMed 17213280 ↗
  • Kusminski CM, McTernan PG, Schraw T, Kos K, O'Hare JP, Ahima R, Kumar S, Scherer PE. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia. 2007 Mar;50(3):634-42. doi: 10.1007/s00125-006-0577-9. Epub 2007 Jan 23. PubMed 17242917 ↗
  • Efstathiou SP, Tsioulos DI, Tsiakou AG, Gratsias YE, Pefanis AV, Mountokalakis TD. Plasma adiponectin levels and five-year survival after first-ever ischemic stroke. Stroke. 2005 Sep;36(9):1915-9. doi: 10.1161/01.STR.0000177874.29849.f0. Epub 2005 Aug 18. PubMed 16109902 ↗
  • Takeuchi S, Wada K, Otani N, Osada H, Nagatani K, Mori K. Temporal profile of plasma adiponectin level and delayed cerebral ischemia in patients with subarachnoid hemorrhage. J Clin Neurosci. 2014 Jun;21(6):1007-10. doi: 10.1016/j.jocn.2013.10.020. Epub 2013 Dec 22. PubMed 24594449 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 31, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02814162
Lead sponsor
Tang-Du Hospital
Responsible party
Sponsor
First posted
Jun 27, 2016
Start date
Apr 2016
Primary completion
Jun 2017 (estimated)
Completion
Aug 2017 (estimated)
Last update
Mar 31, 2017

Study contacts

Yan Qu, M.D Ph.D
Contact
yanqu0123@icloud.com
86-18629074363
Min Li, M.D Ph.D
Contact
neursylm@163.com
86-15319053136

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.

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