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CompletedNCT02810158Updated Oct 19, 2018

Mass Spectral Fingerprinting in Obstructive Sleep Apnoea

An observational study in Obstructive Sleep Apnoea (OSA), Exhaled Breath and Mass Spectrometry, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2018-10-19.

Sponsored by University of Zurich · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
150
Ages
18 Years to 85 Years
Sex
All
01

Study summary

To answer the question whether a previously detected breath profile in patients suffering from obstructive sleep apnoea (OSA) can be found in a cohort of patients with suspected OSA using mass spectrometry (validation study).

02

Conditions studied

  • Obstructive Sleep Apnoea (OSA)
  • Exhaled Breath
  • Mass Spectrometry
03

In context

Apnea

1,422 studies on the registry are indexed under Apnea; 159 are open to participants now.

This study's enrollment of 150 is above the median of 106 across 386 observational studies indexed under Apnea.

Browse Apnea studies →

Lead sponsor

University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients with clinical suspicion of OSA

Inclusion criteria

  • Clinical suspicion of obstructive sleep apnoea syndrome (based on clinical symptoms such as increased daytime sleepiness; Epworth Sleepiness Score (ESS) > 10).
  • Age between 18 and 85 years at study entry.

Exclusion criteria

Exclusion Criteria:

  • None
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
150 participants (actual)
Patient registry
No

Groups and cohorts

  • Patients with suspected OSA

    Persons with clinical suspicion of obstructive sleep apnoea syndrome (OSA)

06

What researchers measure

Primary outcomes

  1. OSA-specific mass spectrometric pattern of VOCs in the exhaled breath

    Concentration of volatile organic compounds (VOCs) in the exhaled breath will be analysed using mass spectrometry

    Time frame: one hour, single measurement, no follow-up

07

Study locations

1 site
  • University Hospital Zurich, Division of Pneumology
    Zurich, ZH 8091, Switzerland
08

References and documents

Publications

  • Nowak N, Engler A, Thiel S, Stoberl AS, Sinues P, Zenobi R, Kohler M. Validation of breath biomarkers for obstructive sleep apnea. Sleep Med. 2021 Sep;85:75-86. doi: 10.1016/j.sleep.2021.06.040. Epub 2021 Jul 3. PubMed 34280868 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 19, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02810158
Lead sponsor
University of Zurich
Collaborators
Swiss Federal Institute of Technology
Responsible party
Sponsor
First posted
Jun 22, 2016
Start date
Jun 2016
Primary completion
May 2018
Completion
May 2018
Last update
Oct 19, 2018

Study contacts

Malcolm Kohler, Prof. MD
principal investigator · University of Zurich

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.

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