An interventional study of HIT and MCT in Hypoxia, sponsored by Chang Gung Memorial Hospital. Completed. Open to male participants aged 20 Years to 28 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-06-16.
Sponsored by Chang Gung Memorial Hospital · Not applicable, Interventional, and Health services research
Exercise training improves endothelium-dependent vasodilation, whereas hypoxic stress causes vascular endothelial dysfunction. Monocyte- derived endothelial progenitor cells (Mon-EPCs) contribute to vascular repair process by differentiating into endothelial cells. This study investigates how high-intensity interval (HIT) and moderate intensity-continuous (MCT) exercise training affect circulating Mon-EPC levels and EPC functionality under hypoxic condition. Sixty healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max , n=20) or MCT (sustained 60%VO2max , n=20) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group that did not received exercise intervention (n=20). Mon-EPC characteristics and EPC functionality under hypoxic exercise (HE, 100W under 12%O 2 ) were determined before and after various interventions.
1,231 studies on the registry are indexed under Hypoxia; 241 are open to participants now.
This study's enrollment of 60 is above the median of 45 across 853 interventional studies indexed under Hypoxia.
Browse Hypoxia studies →Chang Gung Memorial Hospital is the lead sponsor of 1,064 studies on the registry; 235 are open to participants now.
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Exclusion Criteria:
Behavioral: HIT
Behavioral: MCT
3-minute intervals at 40% and 80%VO 2max
sustained 60%VO 2max
Circulating progenitor cells conten
by flow cytometry before and after rehabilitation circulating progenitor cells conten before and after hypoxic exercise test
Time frame: 6 weeks
Cardiopulmonary fitness
Time frame: 6 weeks
Cardiac hemodynamic measurement
evaluate cardiac hemodynamic response to exercise by noninvasive continuous cardiac output monitoring system
Time frame: 6 weeks
Cerebral hemodynamic measurement
Two pairs of near infrared probes were attached to each subject to monitor the absorption of near infrared light across left frontal cortex during graded exercise test
Time frame: 6 weeks
Muscular hemodynamic measurement
Two pairs of near infrared probes were attached to each subject to monitor the absorption of near infrared light across left vastus lateralis muscle during graded exercise test
Time frame: 6 weeks
No study locations are listed for this record.
This study is completed, as verified in Jun 2016. You cannot join it, but the record below documents what was studied.
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Chang Gung Memorial Hospital