An interventional study of Blindfold in Amblyopia, Anisometropia and Visual Impairment, sponsored by Boston Children's Hospital. Withdrawn. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2020-08-04.
Sponsored by Boston Children's Hospital · Not applicable, Interventional, and Treatment
Amblyopia is a significant health problem, affecting up to 4% of the population in the United States. Amblyopia, commonly known as "lazy eye," is a developmental visual disorder in which one or both eyes suffer from poor vision as a result of being disadvantaged in early life. Strabismus, or eye misalignment, such as crossed eyes (esotropia) or wandering eyes (exotropia), and anisometropia, or a power difference between the eyes, are the most common causes of amblyopia. If conventional treatment, such as patching the better seeing eye, is not initiated during the critical period of visual development, lasting visual impairment may persist throughout life. This critical period of visual development has been thought to end around age 10. However, recent research has demonstrated that the critical period of visual development can be extended into adulthood. Complete light deprivation in animal models has restored plasticity in the visual cortex and has demonstrated drastic recovery of vision in amblyopic eyes. The objective of this pilot study is to evaluate the impact of complete light deprivation on visual function in a cohort of human adults with severe amblyopia from anisometropia.
183 studies on the registry are indexed under Amblyopia; 43 are open to participants now.
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Of its 31 completed or terminated interventional studies of FDA-regulated products, 18 (58%) have results posted.
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Exclusion Criteria:
Study subjects who are blindfolded for 48 hours
Device: Blindfold
Study subjects will be blindfolded to create an environment of complete light deprivation which will be worn for 48 hours.
Logmar visual acuity
Time frame: Measured at 60 minutes after blindfold is removed
Logmar visual acuity
Time frame: Measured at one week after blindfold is removed
No study locations are listed for this record.
Plan to share: Yes — Study subject's visual acuity before and after the intervention will be given to the study subject.
No publications or documents are linked to this record.
This study is withdrawn, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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