CClinicalTrials.gg
CompletedNCT02798679Updated Oct 18, 2022

Cardiac Fibrosis and Risk Prediction in Cancer Treatment-Related Cardiotoxicity

An observational study in Cardiotoxicity, sponsored by University of Minnesota. Completed at 1 site in United States. Open to participants aged 45 Years and older. Per ClinicalTrials.gov, last updated 2022-10-18.

Sponsored by University of Minnesota · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
40
Ages
45 Years and older
Sex
All
01

Study summary

The purpose of this study is to determine whether pre-existing cardiac fibrosis is a predictor of cancer treatment-related cardiotoxicity.

02

Conditions studied

  • Cardiotoxicity

Browse trials for

03

In context

Cardiotoxicity

264 studies on the registry are indexed under Cardiotoxicity; 71 are open to participants now.

This study's enrollment of 40 is below the median of 100 across 125 observational studies indexed under Cardiotoxicity.

Browse Cardiotoxicity studies →

Lead sponsor

University of Minnesota is the lead sponsor of 1,184 studies on the registry; 195 are open to participants now.

Of its 132 completed or terminated interventional studies of FDA-regulated products, 91 (69%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Consecutive participants with breast cancer or lymphoma scheduled to receive anthracycline-based chemotherapy or trastuzumab.

Inclusion criteria

  • Stage I-III breast cancer or lymphoma with a >2 year life expectancy
  • A treatment plan that includes anthracyclines and/or trastuzumab
  • Age >45 years
  • Able to hold breath for 10 seconds
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

Exclusion criteria

Exclusion Criteria:

  • Refusal or inability to provide informed consent
  • Known heart failure or LVEF \<50%
  • Heart rate over 100 bpm
  • Renal dysfunction with GFR \<30 mL/min/1.73m2
  • Participants with pacemakers, defibrillators, functioning neurostimulator devices or other implanted electronic devices
  • Symptomatic claustrophobia
  • Plans to move within 24 months of enrollment
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
40 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Cardiotoxicity assessed clinically or by cardiac MRI

    Time frame: 24 months

07

Study locations

1 site
  • University of Minnesota
    Minneapolis, Minnesota 55455, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 18, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02798679
Lead sponsor
University of Minnesota
Responsible party
Sponsor
First posted
Jun 14, 2016
Start date
Aug 2016
Primary completion
Sep 1, 2022
Completion
Sep 1, 2022
Last update
Oct 18, 2022

Study contacts

Chetan Shenoy, MBBS
principal investigator · University of Minnesota

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion