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CompletedNCT02791997Updated Sep 4, 2025

Audition After a Lesion and in Migraine. (AuditionPostLesion)

An interventional study of Neuropsychological tests and Neurophysiological tests in Migraine Disorders, Brain, sponsored by Hospices Civils de Lyon. Completed at 2 sites in France. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-04.

Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 1 year 3 months after the study started (first participant enrolled Feb 2015, registered May 2016).
Phase
Not applicable
Study type
Interventional
Enrollment
262
Allocation
Non-randomized
Ages
18 Years to 80 Years
Sex
All
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Study summary

The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions. To characterize auditory deficits after brain damage or in migraine, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

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Conditions studied

  • Migraine Disorders, Brain

Keywords

  • Audition
  • Stroke
  • Migraine
  • Attention
  • Short-term memory,
  • Emotions
  • EEG
  • MEG
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In context

Migraine Disorders

1,528 studies on the registry are indexed under Migraine Disorders; 299 are open to participants now.

This study's enrollment of 262 is above the median of 80 across 1,175 interventional studies indexed under Migraine Disorders.

Browse Migraine Disorders studies →

Lead sponsor

Hospices Civils de Lyon is the lead sponsor of 1,826 studies on the registry; 439 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age from 18 to 80
  • MEG/MRI compatibility
  • Motivation to participate efficiently in the study
  • No severe hearing loss
  • Informed consent to participate in the study
  • Affiliation to social security
  • For brain-damaged patients : no need for medical assistance; focal temporal and/or frontal lesion; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; testing at least one-month after the event resulting in brain damage; absence of neurological and psychiatric disorders besides the lesion
  • For migraine patients: no need for medical assistance; migraine diagnosis; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; absence of neurological and psychiatric disorders besides the migraine
  • Healthy participants: absence of neurological and psychiatric disorders

Exclusion criteria

Exclusion Criteria:

  • Age below 18 or above 80
  • MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
  • MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
  • Pregnant or breast-feeding women
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
262 participants (actual)

Study arms

  • Experimental
    Brain-damaged patients

    Other: Neuropsychological tests · Other: Neurophysiological tests

  • Experimental
    Control participants

    Other: Neuropsychological tests · Other: Neurophysiological tests

  • Experimental
    Migraine patients

    Other: Neuropsychological tests · Other: Neurophysiological tests

Interventions

  • OtherNeuropsychological tests

    Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.

  • OtherNeurophysiological tests

    Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.

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What researchers measure

Primary outcomes

  1. Percentages of correct responses in Neuropsychological tests

    Time frame: up to 2 months

  2. reaction times in Neuropsychological tests

    Time frame: up to 2 months

Secondary outcomes

  1. Event-Related Potentials (EEG) in Neurophysiological tests

    Time frame: up to 2 months

  2. Event-Related Fields (MEG) in Neurophysiological tests

    Time frame: up to 2 months

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Study locations

2 sites
  • Unité 201, Hôpital Neurologique
    Bron, 69500, France
  • Service Explorations Fonctionnelles Neurologiques, Hôpital de la Croix-Rousse
    Lyon, 69004, France
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References and documents

Publications

  • Masson R, Demarquay G, Meunier D, Leveque Y, Hannoun S, Bidet-Caulet A, Caclin A. Is Migraine Associated to Brain Anatomical Alterations? New Data and Coordinate-Based Meta-analysis. Brain Topogr. 2021 May;34(3):384-401. doi: 10.1007/s10548-021-00824-6. Epub 2021 Feb 19. PubMed 33606142 ↗
  • Masson R, ElShafei A, Demarquay G, Fornoni L, Leveque Y, Caclin A, Bidet-Caulet A. Deficient inhibition of irrelevant visual information in migraine: A magnetoencephalography study of alpha-band activity. Headache. 2026 Jul-Aug;66(7):1459-1473. doi: 10.1111/head.70108. Epub 2026 Jun 15. PubMed 42290392 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 4, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02791997
Lead sponsor
Hospices Civils de Lyon
Responsible party
Sponsor
First posted
Jun 7, 2016
Start date
Feb 6, 2015
Primary completion
Sep 9, 2020
Completion
Sep 9, 2020
Last update
Sep 4, 2025

Study contacts

Norbert NIGHOGHOSSIAN, MD
principal investigator · Unité 201, Hôpital Neurologique, Hospices Civils de Lyon

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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