An observational study in Dental Erosion, sponsored by University of Göttingen. Completed at 1 site in Germany. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-02-14.
Sponsored by University of Göttingen · Observational
Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion.
Total protein concentration within the formed salivary pellicles on the bovine samples is determined. Further Salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, albumin and total protein content as well as concentration of inorganic calcium, phosphate and fluoride) are being measured.
The aim of this study is to investigate whether gender differences in the salivary composition correlate with predisposition to erosion.
47 studies on the registry are indexed under Tooth Erosion; 7 are open to participants now.
This study's enrollment of 50 is below the median of 100 across 13 observational studies indexed under Tooth Erosion.
Browse Tooth Erosion studies →University of Göttingen is the lead sponsor of 37 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exploratory study
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Female volunteers
Other: Wearing of an intraoral device with bovine tooth samples
Male volunteers
Other: Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with bovine tooth samples
Calcium release from bovine enamel and dentin samples by extraoral erosion (nmol/Square Millimeter).
Time frame: Immediately after the intraoral device has been worn once for two hours.
Determination of unstimulated and stimulated saliva flow rate (mL/min).
Time frame: Saliva samples are collected for 5 min each on two visits.
Determination of saliva pH.
Time frame: Saliva samples are collected for 5 min each on two visits.
Determination of salivary buffer capacity.
Time frame: Saliva samples are collected for 5 min each on two visits.
Determination of albumin (mg/L) in saliva.
Time frame: Saliva samples are collected for 5 min each on two visits.
Determination of total protein content (mg/L) in saliva.
Time frame: Saliva samples are collected for 5 min each on two visits.
Determination of inorganic calcium (mmol/l), phosphate (mmol/L) and fluoride (µmol/L) in saliva.
Time frame: Saliva samples are collected for 5 min each on two visits.
Determination of total protein concentration in the formed salivary pellicles (ng/Square Millimeter).
Time frame: Immediately after the intraoral device has been worn once for two hours.
Plan to share: No
Ran from Feb 2017 to primary completion in Jan 2018, 11 months.
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This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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University of Göttingen